日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi‐omics studies reveal convergent and divergent pathways in Alzheimer's and related disorders

多组学研究揭示了阿尔茨海默病及相关疾病中的趋同和分歧通路

Karten, Barbara; Hayashi, Hideki; Francis, Gordon A; Campenot, Robert B; Vance, Dennis E; Vance, Jean E; Allen, Mariet; Oatman, Stephanie R; Wang, Xue; Reddy, Joseph S; Nguyen, Thuy T; Dickson, Dennis W; Ertekin‐Taner, Nilüfer

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

基因筛选揭示磷脂代谢是氧化还原活性脂质辅酶Q生物合成的关键调节因子。

Ayer, Anita; Fazakerley, Daniel J; Suarna, Cacang; Maghzal, Ghassan J; Sheipouri, Diba; Lee, Kevin J; Bradley, Michelle C; Fernández-Del-Rio, Lucía; Tumanov, Sergey; Kong, Stephanie My; van der Veen, Jelske N; Yang, Andrian; Ho, Joshua W K; Clarke, Steven G; James, David E; Dawes, Ian W; Vance, Dennis E; Clarke, Catherine F; Jacobs, René L; Stocker, Roland

From masochistic enzymology to mechanistic physiology and disease

从受虐酶学到机制生理学和疾病

Vance, Dennis E

Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism

基质金属蛋白酶 9 在调节胆固醇代谢中的新作用

Samuel Hernandez-Anzaldo, Vesna Brglez, Bianca Hemmeryckx, Dickson Leung, Janos G Filep, Jean E Vance, Dennis E Vance, Zamaneh Kassiri, Roger H Lijnen, Gérard Lambeau, Carlos Fernandez-Patron

Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT

缺乏 PEMT 的高脂饮食小鼠在暴露于寒冷时,葡萄糖供应不足与体温过低有关

Xia Gao, Jelske N van der Veen, Carlos Fernandez-Patron, Jean E Vance, Dennis E Vance, René L Jacobs

Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action

胆碱补充剂通过增强胰高血糖素作用,促进磷脂酰乙醇胺N-甲基转移酶缺陷小鼠的肝脏胰岛素抵抗。

Wu, Gengshu; Zhang, Liyan; Li, Tete; Zuniga, Azeret; Lopaschuk, Gary D; Li, Liang; Jacobs, René L; Vance, Dennis E

Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance

骨骼肌脂肪酸代谢的改变使中年小鼠更容易出现饮食诱导的胰岛素抵抗。

Koonen, Debby P Y; Sung, Miranda M Y; Kao, Cindy K C; Dolinsky, Vernon W; Koves, Timothy R; Ilkayeva, Olga; Jacobs, René L; Vance, Dennis E; Light, Peter E; Muoio, Deborah M; Febbraio, Maria; Dyck, Jason R B

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity

从头合成胆碱受损可以解释为什么磷脂酰乙醇胺N-甲基转移酶缺陷小鼠能够免受饮食诱导的肥胖症的影响。

Jacobs, René L; Zhao, Yang; Koonen, Debby P Y; Sletten, Torunn; Su, Brian; Lingrell, Susanne; Cao, Guoqing; Peake, David A; Kuo, Ming-Shang; Proctor, Spencer D; Kennedy, Brian P; Dyck, Jason R B; Vance, Dennis E

Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis.

胆碱激酶α基因的破坏导致早期胚胎致死,胆碱激酶α是磷脂酰胆碱生物合成中的第一个酶

Wu Gengshu, Aoyama Chieko, Young Stephen G, Vance Dennis E

Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.

转基因肝外表达甜菜碱-同型半胱氨酸甲基转移酶对酒精或同型半胱氨酸诱导的脂肪肝的影响

Ji Cheng, Shinohara Masao, Vance Dennis, Than Tin Aung, Ookhtens Murad, Chan Christine, Kaplowitz Neil