日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Replication protein A protects lagging strand gaps, restricting PARP inhibitor-induced synthetic lethality in BRCA1-deficient tumors

复制蛋白A保护滞后链缺口,限制PARP抑制剂在BRCA1缺陷型肿瘤中诱导的合成致死性。

VanderVere-Carozza, Pamela S; Jordan, Matthew R; Garrett, Joy E; Pollok, Karen E; Pawelczak, Katherine S; Turchi, John J

Biochemical impact of p300-mediated acetylation of replication protein A: Implications for DNA metabolic pathway choice.

p300介导的复制蛋白A乙酰化的生化影响:对DNA代谢途径选择的意义

Ononye Onyekachi, Surendran Sneha, Battapadi Tripthi, VanderVere-Carozza Pamela, Howald Olivia K, Kantartzis-Petrides Athena, Jordan Matthew R, Ainembabazi Diana, Wold Marc S, Turchi John J, Balakrishnan Lata

Design, synthesis, and structure-activity relationship studies of 4-substituted phenylpyrazolidinone derivatives as potent Ku70/80 targeted DNA-PK inhibitors

4-取代苯基吡唑烷酮衍生物作为强效Ku70/80靶向DNA-PK抑制剂的设计、合成及构效关系研究

Kushwaha, Narva Deshwar; VanderVere-Carozza, Pamela; Vernon, Tyler L; Mendoza-Munoz, Pamela L; Gaddameedi, Jitender D; Ben Ali Gacem, Karim; Engel, Joseph; Charbonnier, Jean-Baptiste; Gavande, Navnath S; Turchi, John J

Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks

Ku-DNA 结合抑制剂调节 DNA 双链断裂引起的 DNA 损伤反应

Pamela L Mendoza-Munoz, Navnath S Gavande, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Joseph R Dynlacht, Joy E Garrett, John J Turchi

In Vivo Targeting Replication Protein A for Cancer Therapy

体内靶向复制蛋白 A 进行癌症治疗

Pamela S VanderVere-Carozza, Navnath S Gavande, Shadia I Jalal, Karen E Pollok, Elmira Ekinci, Joshua Heyza, Steve M Patrick, Andi Masters, John J Turchi, Katherine S Pawelczak

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

复制间隙是 BRCA 缺陷患者 PARP 抑制剂合成致死的关键决定因素

Ke Cong, Min Peng, Arne Nedergaard Kousholt, Wei Ting C Lee, Silviana Lee, Sumeet Nayak, John Krais, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Jennifer Calvo, Nicholas J Panzarino, John J Turchi, Neil Johnson, Jos Jonkers, Eli Rothenberg, Sharon B Cantor

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction

通过针对独特的 Ku-DNA 相互作用发现和开发新型 DNA-PK 抑制剂

Navnath S Gavande, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Pamela Mendoza-Munoz, Tyler L Vernon, Leslyn A Hanakahi, Matthew Summerlin, Joseph R Dynlacht, Annabelle H Farmer, Catherine R Sears, Nawar Al Nasrallah, Joy Garrett, John J Turchi

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer

在卵巢癌中,铂诱导的 RING1A 对磷酸化 H2AX 的泛素化由复制蛋白 A 介导

Shruthi Sriramkumar, Timothy D Matthews, Ahmed H Ghobashi, Samuel A Miller, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Kenneth P Nephew, John J Turchi, Heather M O'Hagan

Testing the metal of ERCC2 in predicting the response to platinum-based therapy

检测ERCC2金属在预测铂类药物治疗反应中的作用

Turchi, John J; Woods, Derek S; VanderVere-Carozza, Pamela

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation

揭示 DNA 依赖性蛋白激酶自身磷酸化的复杂性

Jessica A Neal, Seiji Sugiman-Marangos, Pamela VanderVere-Carozza, Mike Wagner, John Turchi, Susan P Lees-Miller, Murray S Junop, Katheryn Meek