日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma

缺氧会促进BCMA丢失和抑制性分泌组的形成，从而阻碍CAR-T细胞疗法在多发性骨髓瘤中的应用。

期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-025-00732-6
Tu, Chenggong; Van der Vreken, Arne; Meeus, Fien; van den Broecke, Lauren; Brons, Jack; De Veirman, Kim; Vanderkerken, Karin; De Bruyne, Elke; Breckpot, Karine; Menu, Eline
T细胞
多发性骨髓瘤
T细胞
骨髓瘤
细胞生物学
免疫/内分泌
发表日期：2026
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PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

骨髓基质细胞中 PYCR1 的抑制可通过改变其代谢来增强多发性骨髓瘤细胞对硼替佐米的敏感性。

期刊:Molecular Oncology
影响因子:4.5
doi:10.1002/1878-0261.70120
Oudaert, Inge; van den Broecke, Lauren; Aksoy, Osman; Lind, Judith; Vallet, Sonia; Van der Vreken, Arne; Ates, Gamze; Massie, Ann; Maes, Ken; De Veirman, Kim; De Bruyne, Elke; Vanderkerken, Karin; Podar, Klaus; Menu, Eline
CR1
多发性骨髓瘤
代谢
基质细胞
PYC
骨髓瘤
细胞生物学
发表日期：2026
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Leveraging Digital Technology and Artificial Intelligence to Describe the Real-World Belgian Chronic Lymphocytic Leukemia Patient Population: The BE-CLLEAR Study

利用数字技术和人工智能描述比利时慢性淋巴细胞白血病患者群体的真实情况：BE-CLLEAR 研究

期刊:JCO Clinical Cancer Informatics
影响因子:2.8
doi:10.1200/CCI-25-00159
Vanderkerken, Matthias; Van Eygen, Koen; Galle, Veerle; Verbiest, Annelies; Janssens, Ann; Masuy, Imke; Theys, Kristof; Cuppens, Tine; Muylle, Katoo; De Becker, Ann
白血病
细胞生物学
发表日期：2026
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Correction: Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma

更正：用于局部治疗多发性骨髓瘤溶骨性骨病和微小残留病灶的硼替佐米释放二氧化硅-胶原蛋白干凝胶

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-025-01663-9
Hose, Dirk; Ray, Seemun; Rößler, Sina; Thormann, Ulrich; Schnettler, Reinhard; de Veirman, Kim; Khassawna, Thaqif El; Heiss, Christian; Hild, Anne; Zahner, Daniel; Alagboso, Francisca; Henss, Anja; Beck, Susanne; Emde-Rajaratnam, Martina; Burhenne, Jürgen; Bamberger, Juliane; Menu, Eline; de Bruyne, Elke; Gelinsky, Michael; Kampschulte, Marian; Rohnke, Marcus; Wenisch, Sabine; Vanderkerken, Karin; Hanke, Thomas; Seckinger, Anja; Alt, Volker
多发性骨髓瘤
骨髓瘤
发表日期：2025
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B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape

基于B7-H3纳米抗体的CAR-T细胞可控制多发性骨髓瘤的生长，而双重BCMA/B7-H3 CAR-T细胞则可克服抗原逃逸。

期刊:Journal of Hematology & Oncology
影响因子:29.5
doi:10.1186/s13045-025-01756-5
Arne Van der Vreken ，Fien Meeus ，Chenggong Tu ，Lauren van den Broecke ，Vincenzo Raimondi ，Rosanna Vescovini ，Heleen Hanssens ，Fenja Watté ，Dorien Autaers ，Marta Marco Aragon ，Janne Billiau ，Kim De Veirman ，Karin Vanderkerken ，Yannick De Vlaeminck ，Lorenzo Franceschini ，Holly Lee ，Paola Neri ，Elke De Bruyne ，Paola Storti ，Nicola Giuliani ，Karine Breckpot # ，Eline Menu #
骨髓瘤
B7-H3
T细胞
发表日期：2025
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Syntenin inhibition impairs stroma-tumor communication in multiple myeloma and improves bortezomib treatment efficiency.

Syntenin 抑制剂会损害多发性骨髓瘤中的基质-肿瘤通讯，并提高硼替佐米治疗的疗效

期刊:Hemasphere
影响因子:14.6
doi:10.1002/hem3.70197
Tu Chenggong, Leblanc Raphael, Van der Vreken Arne, Koops Marnix, Audebert Stephane, Goullieux Lauriane, Meeussen Sofie, De Veirman Kim, De Bruyne Elke, Vanderkerken Karin, David Guido, Cupedo Tom, Zimmermann Pascale, Menu Eline
肿瘤
发表日期：2025
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The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse

从头DNA甲基转移酶3B是多发性骨髓瘤中MYC的一种新型表观遗传调控因子，代表了一种有前景的治疗靶点，可用于对抗复发

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03382-y
Muylaert, Catharina; Van Hemelrijck, Lien Ann; Van der Vreken, Arne; Heestermans, Robbe; Satilmis, Hatice; Verheye, Emma; Alaterre, Elina; Olsen, Catharina; De Beule, Nathan; De Veirman, Kim; Menu, Eline; Vanderkerken, Karin; Moreaux, Jérôme; De Bruyne, Elke
表观遗传
多发性骨髓瘤
信号转导
骨髓瘤
MYC
发表日期：2025
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Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy

免疫肽组学鉴定出用于多发性骨髓瘤治疗中含α-半乳糖神经酰胺的mRNA-脂质纳米颗粒疫苗的抗原

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2024-010673
Van der Vreken, Arne; Thery, Fabien; Tu, Chenggong; Mwangi, Kevin; Meulewaeter, Sofie; De Beck, Lien; Janssens, Edith; De Veirman, Kim; Vanderkerken, Karin; De Bruyne, Elke; Franceschini, Lorenzo; Impens, Francis; Verbeke, Rein; Lentacker, Ine; Menu, Eline; Breckpot, Karine
多发性骨髓瘤
免疫/内分泌
骨髓瘤
发表日期：2025
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A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages.

小鼠和人类多发性骨髓瘤免疫微环境在疾病各个阶段的单细胞转录组图谱

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-024-01629-3
Verheye Emma, Kancheva Daliya, Satilmis Hatice, Vandewalle Niels, Fan Rong, Bardet Pauline M R, Clappaert Emile J, Verstaen Kevin, De Becker Ann, Vanderkerken Karin, De Veirman Kim, Laoui Damya
细胞生物学
Human
单细胞
发表日期：2024
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Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

CAR-T细胞疗法的动力来源：代谢策略

期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-024-00535-1
Van der Vreken, Arne; Vanderkerken, Karin; De Bruyne, Elke; De Veirman, Kim; Breckpot, Karine; Menu, Eline
T细胞
代谢
T细胞
细胞生物学
免疫/内分泌
发表日期：2024
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