日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimizing anti-PI3Kδ and anti-LAG-3 immunotherapy dosing regimens in a mouse model of triple-negative breast cancer improves outcome by removing treatment-related adverse events.

在三阴性乳腺癌小鼠模型中优化抗 PI3Kδ 和抗 LAG-3 免疫疗法的给药方案,可消除与治疗相关的不良事件,从而改善治疗效果。

Lauder Sarah Nicol, Pires Ana, Somerville Michelle, Capitani Lorenzo, Smart Kathryn, Geary James, Mills Emily M, Vanhaesebroeck Bart, Godkin Andrew, Gallimore Awen

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.

PI3K-C2α失活会扰乱细胞死亡途径,并使细胞对内毒素休克更加敏感

Posor York, Conduit Sarah E, Pearce Wayne, Morelli Daniele, Constantinou Georgia, Whitehead Maria, Sebire Neil J, Scudamore Cheryl L, Peltzer Nieves, Walczak Henning, Vanhaesebroeck Bart

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality.

PI3Kβ通过调节A系统氨基酸转运蛋白的表达在胎盘功能中发挥新作用,与胚胎致死有关。

Conduit Sarah E, Zhang Cindy X W, Pearce Wayne, Guillermet-Guibert Julie, Sferruzzi-Perri Amanda N, Vanhaesebroeck Bart

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

mTOR通路疾病:从实验室到临床的挑战与机遇以及mTOR节点

Mantoan Ritter, Laura; Annear, Nicholas M P; Baple, Emma L; Ben-Chaabane, Leila Y; Bodi, Istvan; Brosson, Lauren; Cadwgan, Jill E; Coslett, Bryn; Crosby, Andrew H; Davies, D Mark; Daykin, Nicola; Dedeurwaerdere, Stefanie; Dühring Fenger, Christina; Dunlop, Elaine A; Elmslie, Frances V; Girodengo, Marie; Hambleton, Sophie; Jansen, Anna C; Johnson, Simon R; Kearley, Kelly C; Kingswood, John C; Laaniste, Liisi; Lachlan, Katherine; Latchford, Andrew; Madsen, Ralitsa R; Mansour, Sahar; Mihaylov, Simeon R; Muhammed, Louwai; Oliver, Claire; Pepper, Tom; Rawlins, Lettie E; Schim van der Loeff, Ina; Siddiqui, Ata; Takhar, Pooja; Tatton-Brown, Katrina; Tee, Andrew R; Tibarewal, Priyanka; Tye, Charlotte; Ultanir, Sila K; Vanhaesebroeck, Bart; Zare, Benjamin; Pal, Deb K; Bateman, Joseph M

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

30 years of PI3K: an interview with Bart Vanhaesebroeck

PI3K 三十周年:巴特·范哈塞布鲁克访谈录

Vanhaesebroeck, Bart

Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation

通过选择性降解精准靶向癌症中的突变型PI3Kα

Vanhaesebroeck, Bart; Burke, John E; Madsen, Ralitsa R

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma

嗅神经母细胞瘤的临床结果、Kadish-INSICA分期和生长抑素受体2的治疗靶向治疗

Lechner, Matt; Takahashi, Yoko; Turri-Zanoni, Mario; Liu, Jacklyn; Counsell, Nicholas; Hermsen, Mario; Kaur, Raman Preet; Zhao, Tianna; Ramanathan, Murugappan Jr; Schartinger, Volker H; Emanuel, Oscar; Helman, Sam; Varghese, Jordan; Dudas, Jozsef; Riechelmann, Herbert; Sprung, Susanne; Haybaeck, Johannes; Howard, David; Engel, Nils Wolfgang; Stewart, Sarah; Brooks, Laura; Pickles, Jessica C; Jacques, Thomas S; Fenton, Tim R; Williams, Luke; Vaz, Francis M; O'Flynn, Paul; Stimpson, Paul; Wang, Simon; Hannan, S Alam; Unadkat, Samit; Hughes, Jonathan; Dwivedi, Raghav; Forde, Cillian T; Randhawa, Premjit; Gane, Simon; Joseph, Jonathan; Andrews, Peter J; Royle, Gary; Franchi, Alessandro; Maragliano, Roberta; Battocchio, Simonetta; Bewicke-Copley, Helen; Pipinikas, Christodoulos; Webster, Amy; Thirlwell, Chrissie; Ho, Debbie; Teschendorff, Andrew; Zhu, Tianyu; Steele, Christopher D; Pillay, Nischalan; Vanhaesebroeck, Bart; Mohyeldin, Ahmed; Fernandez-Miranda, Juan; Park, Ki Wan; Le, Quynh-Thu; West, Robert B; Saade, Rami; Manes, R Peter; Omay, Sacit Bulent; Vining, Eugenia M; Judson, Benjamin L; Yarbrough, Wendell G; Sansovini, Maddalena; Silvia, Nicolini; Grassi, Ilaria; Bongiovanni, Alberto; Capper, David; Schüller, Ulrich; Thavaraj, Selvam; Sandison, Ann; Surda, Pavol; Hopkins, Claire; Ferrari, Marco; Mattavelli, Davide; Rampinelli, Vittorio; Facchetti, Fabio; Nicolai, Piero; Bossi, Paolo; Henriquez, Oswaldo A; Magliocca, Kelly; Solares, C Arturo; Wise, Sarah K; Llorente, Jose L; Patel, Zara M; Nayak, Jayakar V; Hwang, Peter H; Lacy, Peter D; Woods, Robbie; O'Neill, James P; Jay, Amrita; Carnell, Dawn; Forster, Martin D; Ishii, Masaru; London, Nyall R Jr; Bell, Diana M; Gallia, Gary L; Castelnuovo, Paolo; Severi, Stefano; Lund, Valerie J; Hanna, Ehab Y

Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development

用低剂量雷帕霉素长期治疗易患癌症的生殖系PTEN突变小鼠,可延长其寿命并延缓肿瘤发展。

Tibarewal, Priyanka; Rathbone, Victoria; Constantinou, Georgia; Pearce, Wayne; Adil, Mahreen; Varyova, Zofia; Folkes, Lisa; Hampson, Alix; Classen, Gala Anastasia Electra; Alves, Adriana; Carvalho, Sara; Scudamore, Cheryl L; Vanhaesebroeck, Bart

PI3K inhibitors are finally coming of age

PI3K抑制剂终于走向成熟

Vanhaesebroeck, Bart; Perry, Matthew W D; Brown, Jennifer R; André, Fabrice; Okkenhaug, Klaus