日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms

一种基于细胞的定量报告系统将TDP-43聚集和功能障碍联系起来,从而阐明其致病机制。

Mamede, Lohany Dias; Hu, Miwei; Vaquer-Alicea, Jaime; Titus, Amanda R; Passos, Patricia M; Lantelme, Erica; French, Rachel L; Kirschner, Paige A; Diamond, Marc I; Miller, Timothy M; Ayala, Yuna M

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells

半胱氨酸是细胞内自发性和种子诱导的tau蛋白聚集的关键决定因素。

Jayan, Parvathy; Rastogi, Simran; Bommareddy, Vaibhav; Dashnaw, Chad M; Vaquer-Alicea, Jaime; Nguyen, Binh An; Saelices, Lorena; Shahmoradian, Sarah; White, Charles L 3rd; Diamond, Marc I; Joachimiak, Lukasz A

VCP regulates early tau seed amplification via specific cofactors

VCP通过特定辅助因子调控早期tau种子扩增

Batra, Sushobhna; Vaquer-Alicea, Jaime; Valdez, Clarissa; Taylor, Skyler P; Manon, Victor A; Vega, Anthony R; Kashmer, Omar M; Kolay, Sourav; Lemoff, Andrew; Cairns, Nigel J; White, Charles L 3rd; Diamond, Marc I

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE,导致神经元tau蛋白病理和毒性增加

Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Miller Bruce L, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A

Functional classification of tauopathy strains reveals the role of protofilament core residues

tau蛋白病菌株的功能分类揭示了原丝核心残基的作用

Vaquer-Alicea, Jaime; Manon, Victor A; Bommareddy, Vaibhav; Kunach, Peter; Gupta, Ankit; Monistrol, Jim; Perez, Valerie A; Tran, Hung Tri; Saez-Calveras, Nil; Du, Siling; Batra, Sushobhna; Stoddard, Daniel; White, Charles L 3rd; Joachimiak, Lukasz A; Shahmoradian, Sarah H; Diamond, Marc I

Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy

伴有tau蛋白病理的特发性震颤的特征性种子在形态上与阿尔茨海默病和原发性年龄相关性tau蛋白病无法区分。

Saez-Calveras, Nil; Vaquer-Alicea, Jaime; White, Charles L 3rd; Tak, Yogesh; Cosentino, Stephanie; Faust, Phyllis L; Louis, Elan D; Diamond, Marc I

Plasma glial fibrillary acidic protein as a biomarker of acute focal brain injury after high-intensity focused ultrasound thalamotomy

血浆胶质纤维酸性蛋白作为高强度聚焦超声丘脑切开术后急性局灶性脑损伤的生物标志物

Saez-Calveras, Nil; Asturias, Alexander; Yu, James; Stopschinski, Barbara; Vaquer-Alicea, Jaime; O'Suilleabhain, Padraig; McKenzie, Lauren; Viera, Jeniz; Diamond, Marc I; Shah, Bhavya R

TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction

TDP-43 聚集接种会损害自身调节并导致 TDP-43 功能障碍

Lohany Dias Mamede, Miwei Hu, Amanda R Titus, Jaime Vaquer-Alicea, Rachel L French, Marc I Diamond, Timothy M Miller, Yuna M Ayala

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) features CTE-like tau seeds in brain and spinal cord

关岛肌萎缩侧索硬化症/帕金森病-痴呆综合征(ALS/PDC)的特征是脑和脊髓中存在类似慢性创伤性脑病(CTE)的tau蛋白种子

Saez-Calveras, Nil; Verheijen, Bert M; Morgan, Nabil; Hill, Elizabeth; Taylor, Skyler; Oyanagi, Kiyomitsu; Kakita, Akiyoshi; Song, Yuyu; Joachimiak, Lukasz A; Vaquer-Alicea, Jaime; Diamond, Marc I; Lu, Ying

DnaJB1 chaperone inhibits tau aggregation by recognizing its N-terminus.

DnaJB1分子伴侣通过识别tau蛋白的N端来抑制tau蛋白的聚集。

Wydorski Pawel M, Macierzynska Paulina, Bali Sofia, Vaquer-Alicea Jaime, Joachimiak Lukasz A