日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques

恒河猴停止抗逆转录病毒治疗后SIV病毒反弹的初始部位

Keele, Brandon F; Okoye, Afam A; Immonen, Taina T; Varco-Merth, Benjamin; Duell, Derick; Nkoy, Candice; Goodwin, William; Hoffmeister, Shelby; Hughes, Colette M; Kose, Emek; Conchas, Andrew; Goodman, Charles A; Fennessey, Christine M; Macairan, Agatha; Bosche, William J; Fast, Randy; Homick, Christopher M; Hull, Mike; Oswald, Kelli; Shoemaker, Rebecca; Silipino, Lorna; Welker, Jorden L; Smedley, Jeremy; Labriola, Caralyn S; Axthelm, Michael K; Hansen, Scott G; Estes, Jacob D; Barouch, Dan H; Lifson, Jeffrey D; Picker, Louis J

Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.

在 ART 中断之前增强 SIV 特异性 CD8+ T 细胞反应可延长 SIVmac239 反弹的时间。

Omange Were R, Varco-Merth Benjamin D, Fadeyi Omo, Marenco Alejandra, Takata Hiroshi, Duell Derick M, Goodwin William D, Armitage Paula, Fennessey Christine M, Kose Emek, Immonen Taina T, Kosmider Ewelina, Bosche William J, Fast Randy, Homick Chris, Oswald Kelli, Shoemaker Rebecca, Bochart Rachele, MacAllister Rhonda, Labriola Caralyn S, Smedley Jeremy V, Axthelm Michael K, Edlefsen Paul T, Keele Brandon F, Lifson Jeffrey D, Gergen Janina, Petsch Benjamin, Rauch Susanne, Picker Louis J, Okoye Afam A

Histone decrotonylation plays a distinct role in HIV latency

组蛋白去泛素化在HIV潜伏期中发挥着独特的作用

Li, Xiaoyi; Li, Dajiang; Tang, Yuyang; Nearing, Marie; Varco-Merth, Benjamin; Chen, Hongjie; Smith, Davey; Gianella, Sara; Archin, Nancie M; Okoye, Afam A; Dandekar, Satya; Margolis, David M; Chirasani, Venkat R; Gumpper, Ryan H; Jiang, Guochun

Dissecting the steps in early simian immunodeficiency virus dissemination following mucosal and intravenous infection of rhesus macaques

剖析恒河猴黏膜和静脉感染后早期猴免疫缺陷病毒传播的步骤

Docken, Steffen S; Macairan, Agatha; Schlub, Timothy E; Fennessey, Christine M; Varco-Merth, Benjamin; Picker, Louis J; Okoye, Afam A; Immonen, Taina T; Cromer, Deborah; Keele, Brandon F; Davenport, Miles P

Identification of initial sites of SIV rebound after treatment cessation

确定治疗停止后SIV反弹的初始部位

Picker, Louis; Keele, Brandon; Okoye, Afam; Immonen, Taina; Varco-Merth, Benjamin; Duell, Derick; Nkoy, Candice; Goodwin, William; Hoffmeister, Shelby; Kose, Emek; Conchas, Andrew; Goodman, Charles; Fennessey, Christine; Macairan, Agatha; Bosche, William; Fast, Randy; Homick, Christopher; Hull, Michael; Oswald, Kelli; Shoemaker, Rebecca; Silipino, Lorna; Welker, Jorden; Smedley, Jeremy; Labriola, Caralyn; Axthelm, Michael; Estes, Jacob; Barouch, Dan; Lifson, Jeffrey

Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers

抗PD-1嵌合抗原受体T细胞能有效靶向生发中心的SIV感染CD4+ T细胞

Eichholz, Karsten; Fukazawa, Yoshinori; Peterson, Christopher W; Haeseleer, Francoise; Medina, Manuel; Hoffmeister, Shelby; Duell, Derick M; Varco-Merth, Benjamin D; Dross, Sandra; Park, Haesun; Labriola, Caralyn S; Axthelm, Michael K; Murnane, Robert D; Smedley, Jeremy V; Jin, Lei; Gong, Jiaxin; Rust, Blake J; Fuller, Deborah H; Kiem, Hans-Peter; Picker, Louis J; Okoye, Afam A; Corey, Lawrence

Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence

阿仑单抗介导的淋巴细胞耗竭对SIV病毒库建立和持续存在的影响

Benjamin Varco-Merth ,Morgan Chaunzwa ,Derick M Duell ,Alejandra Marenco ,William Goodwin ,Rachel Dannay ,Michael Nekorchuk ,Danica Shao ,Kathleen Busman-Sahay ,Christine M Fennessey ,Lorna Silipino ,Michael Hull ,William J Bosche ,Randy Fast ,Kelli Oswald ,Rebecca Shoemaker ,Rachele Bochart ,Rhonda MacAllister ,Caralyn S Labriola ,Jeremy V Smedley ,Michael K Axthelm ,Miles P Davenport ,Paul T Edlefsen ,Jacob D Estes ,Brandon F Keele ,Jeffrey D Lifson ,Sharon R Lewin ,Louis J Picker ,Afam A Okoye

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

在感染SIV的恒河猴中,早期抗逆转录病毒疗法揭示了具有反弹能力的病毒库的多相、可饱和的动态积累过程。

Brandon F Keele ,Afam A Okoye ,Christine M Fennessey ,Benjamin Varco-Merth ,Taina T Immonen ,Emek Kose ,Andrew Conchas ,Mykola Pinkevych ,Leslie Lipkey ,Laura Newman ,Agatha Macairan ,Marjorie Bosche ,William J Bosche ,Brian Berkemeier ,Randy Fast ,Mike Hull ,Kelli Oswald ,Rebecca Shoemaker ,Lorna Silipino ,Robert J Gorelick ,Derick Duell ,Alejandra Marenco ,William Brantley ,Jeremy Smedley ,Michael Axthelm ,Miles P Davenport ,Jeffrey D Lifson ,Louis J Picker

Effects of Early Antiretroviral Therapy on the Composition and Diversity of the Fecal Microbiome of SIV-infected Rhesus Macaques (Macaca mulatta)

早期抗逆转录病毒疗法对感染SIV的恒河猴(Macaca mulatta)粪便微生物组组成和多样性的影响

Lavinder, Tiffany R; Fachko, Devin N; Stanton, Jeffrey; Varco-Merth, Benjamin; Smedley, Jeremy; Okoye, Afam A; Skalsky, Rebecca L

CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification

CD8+ T 细胞在停止抗逆转录病毒治疗后,直到病毒扩增后才能限制 SIV 的再激活,而此时 CD8+ T 细胞在病毒扩增后才能发挥作用。

Afam A Okoye ,Derick D Duell ,Yoshinori Fukazawa ,Benjamin Varco-Merth ,Alejandra Marenco ,Hannah Behrens ,Morgan Chaunzwa ,Andrea N Selseth ,Roxanne M Gilbride ,Jason Shao ,Paul T Edlefsen ,Romas Geleziunas ,Mykola Pinkevych ,Miles P Davenport ,Kathleen Busman-Sahay ,Michael Nekorchuk ,Haesun Park ,Jeremy Smedley ,Michael K Axthelm ,Jacob D Estes ,Scott G Hansen ,Brandon F Keele ,Jeffery D Lifson ,Louis J Picker