日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

GRK2 突变会损害 Hedgehog 和经典 Wnt 信号,从而导致 Jeune 综合征

Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

成纤维细胞生长因子受体通过与肠细胞激酶相互作用影响初级纤毛长度

Michaela Kunova Bosakova, Alexandru Nita, Tomas Gregor, Miroslav Varecha, Iva Gudernova, Bohumil Fafilek, Tomas Barta, Neha Basheer, Sara P Abraham, Lukas Balek, Marketa Tomanova, Jana Fialova Kucerova, Juraj Bosak, David Potesil, Jennifer Zieba, Jieun Song, Peter Konik, Sohyun Park, Ivan Duran, Zby

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

肌醇磷酸酶SHIP2通过募集Src激酶,使FGF受体下游的ERK持续激活。

Fafilek, Bohumil; Balek, Lukas; Bosakova, Michaela Kunova; Varecha, Miroslav; Nita, Alexandru; Gregor, Tomas; Gudernova, Iva; Krenova, Jitka; Ghosh, Somadri; Piskacek, Martin; Jonatova, Lucie; Cernohorsky, Nicole H; Zieba, Jennifer T; Kostas, Michal; Haugsten, Ellen Margrethe; Wesche, Jørgen; Erneux, Christophe; Trantirek, Lukas; Krakow, Deborah; Krejci, Pavel

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies

成纤维细胞生长因子信号调节纤毛功能,可将 FGFR3 相关疾病软骨发育不全和致死性发育不良识别为纤毛病

Michaela Kunova Bosakova, Miroslav Varecha, Marek Hampl, Ivan Duran, Alexandru Nita, Marcela Buchtova, Hana Dosedelova, Radek Machat, Yangli Xie, Zhenhong Ni, Jorge H Martin, Lin Chen, Gert Jansen, Deborah Krakow, Pavel Krejci

One reporter for in-cell activity profiling of majority of protein kinase oncogenes

一个用于分析大多数蛋白激酶致癌基因细胞内活性的报告基因

Iva Gudernova, Silvie Foldynova-Trantirkova, Barbora El Ghannamova, Bohumil Fafilek, Miroslav Varecha, Lukas Balek, Eva Hruba, Lucie Jonatova, Iva Jelinkova, Michaela Kunova Bosakova, Lukas Trantirek, Jiri Mayer, Pavel Krejci

Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

抑制剂再利用表明 ALK、LTK、FGFR、RET 和 TRK 激酶是 AZD1480 的靶点

Iva Gudernova, Lukas Balek, Miroslav Varecha, Jana Fialova Kucerova, Michaela Kunova Bosakova, Bohumil Fafilek, Veronika Palusova, Stjepan Uldrijan, Lukas Trantirek, Pavel Krejci

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

肠细胞激酶 ICK 的失活突变会损害刺猬信号并导致短肋多指综合征

S Paige Taylor, Michaela Kunova Bosakova, Miroslav Varecha, Lukas Balek, Tomas Barta, Lukas Trantirek, Iva Jelinkova, Ivan Duran, Iva Vesela, Kimberly N Forlenza, Jorge H Martin, Ales Hampl; University of Washington Center for Mendelian Genomics; Michael Bamshad, Deborah Nickerson, Margie L Jaworski