日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Advances in the structural understanding of opioid allostery

阿片类药物变构结构理解的进展

Ramos-Gonzalez, Nokomis; Varga, Balazs R; Majumdar, Susruta

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Michael Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma M; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

μ-阿片受体配体效力的非平衡快照

Robertson, Michael J; Papasergi-Scott, Makaía M; Peroto, Maria Claudia; Varga, Balazs R; Majumdar, Susruta; Skiniotis, Georgios

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

配体与μ阿片受体钠位点的水分子相互作用介导的信号调控

Ople, Rohini S; Ramos-Gonzalez, Nokomis; Li, Qiongyu; Sobecks, Briana L; Aydin, Deniz; Powers, Alexander S; Faouzi, Abdelfattah; Polacco, Benjamin J; Bernhard, Sarah M; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel O; Tsai, Bowen A; Dror, Ron O; Varga, Balazs R; Wang, Haoqing; Hüttenhain, Ruth; McLaughlin, Jay P; Majumdar, Susruta

Exercise Types: Physical Activity Mitigates Cardiac Aging and Enhances Mitochondrial Function via PKG-STAT3-Opa1 Axis.

运动类型:体育活动通过 PKG-STAT3-Opa1 轴减轻心脏衰老并增强线粒体功能

Szekeres Reka, Priksz Daniel, Bombicz Mariann, Pelles-Tasko Beata, Szilagyi Anna, Bernat Brigitta, Posa Aniko, Varga Balazs, Gesztelyi Rudolf, Somodi Sandor, Szabo Zoltan, Szilvassy Zoltan, Juhasz Bela

Structure-based design of bitopic ligands for the µ-opioid receptor

基于结构的μ-阿片受体双位点配体设计

Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta