日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

FOXJ1 mediates taxane resistance through regulation of microtubule dynamics.

FOXJ1 通过调节微管动力学介导紫杉烷类药物耐药性。

Xie Fang, Gjyrezi Ada, Fein Daniel, Labaf Maryam, Poluben Larysa, Ersoy-Fazlioglu Betul, Dennehy Christopher M, Voznesensky Olga, Gad Aniket, Corey Eva, Varkaris Andreas, Einstein David J, Bhatt Rupal S, Giannakakou Paraskevi, Balk Steven P

Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.

阐明针对致命性前列腺癌的 MCL1 分子分层单药和联合治疗策略。

Jiménez-Vacas Juan M, Westaby Daniel, Figueiredo Ines, De Haven Brandon Alexis, Padilha Ana, Yuan Wei, Seed George, Bogdan Denisa, Gurel Bora, Bertan Claudia, Miranda Susana, Lambros Maryou, Montero-Hidalgo Antonio J, Coleman Ilsa, Yu Ivan Pak Lok, Buroni Lorenzo, Zeng Wanting, Neeb Antje J, Welti Jon, Rekowski Jan, Paravati Roberta, Gabel Florian, Pandell Nicole, Ferreira Ana, Crespo Mateus, Riisnaes Ruth, Das Souvik, Taylor Joe, Waldron Nick, Hobern Emily, Valenti Melanie, Ning Jian, Bernett Ilona, Liodaki Kate, Persse Thomas, Galipeau Patricia, Wilkinson Scott, Trostel Shana Y, Karzai Fatima, Chau Cindy H, Beatson Erica L, Zhang Xiaohu, Klumpp-Thomas Carleen, Varkaris Andreas, Luque Raul M, Swain Amanda, Raynaud Florence, Lack Nathan A, Thomas Craig J, Ha Gavin, Figg William D, Bezzi Marco, Sowalsky Adam G, Nelson Peter S, Carreira Suzanne, Balk Steven P, de Bono Johann S, Sharp Adam

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.

转移性乳腺癌患者中TOP1突变和抗体药物偶联物的交叉耐药性

Abelman Rachel O, Wu Bogang, Barnes Haley, Medford Arielle, Norden Bryanna, Putur Annika, Bitman Elena, Thant Win, Liu Ting, Weipert Caroline, Fell Geoffrey, Spring Laura M, Wander Seth A, Moy Beverly, Vidula Neelima, Isakoff Steven J, Varkaris Andreas, Juric Dejan, Corcoran Ryan B, Ellisen Leif W, Bardia Aditya

BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity

BCL2表达在具有谱系可塑性特征的晚期前列腺癌中富集

Westaby, Daniel; Jiménez-Vacas, Juan M; Figueiredo, Ines; Rekowski, Jan; Pettinger, Claire; Gurel, Bora; Lundberg, Arian; Bogdan, Denisa; Buroni, Lorenzo; Neeb, Antje; Padilha, Ana; Taylor, Joe; Zeng, Wanting; Das, Souvik; Hobern, Emily; Riisnaes, Ruth; Crespo, Mateus; Miranda, Susana; Ferreira, Ana; Hanratty, Brian P; Nava Rodrigues, Daniel; Bertan, Claudia; Seed, George; Fenor de La Maza, Maria de Los Dolores; Guo, Christina; Carmichael, Juliet; Grochot, Rafael; Chandran, Khobe; Stavridi, Anastasia; Varkaris, Andreas; Stylianou, Nataly; Hollier, Brett G; Tunariu, Nina; Balk, Steven P; Carreira, Suzanne; Yuan, Wei; Nelson, Peter S; Corey, Eva; Haffner, Michael; de Bono, Johann; Sharp, Adam

A Case of Prostate Cancer Harboring Androgen Receptor T878A Progesterone-Responsive Mutant Emerging After Abiraterone Acetate Treatment Responding to Darolutamide

一例前列腺癌患者,其携带雄激素受体T878A孕激素反应性突变,在接受醋酸阿比特龙治疗后出现,对达罗鲁胺治疗有效。

Varkaris, Andreas; Stevens, Julia; Ono, Yuho; Balk, Steven P; Bellmunt, Joaquim

Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma

卡博替尼治疗肾细胞癌脑转移患者的临床活性和安全性

Hirsch, Laure; Martinez Chanza, Nieves; Farah, Subrina; Xie, Wanling; Flippot, Ronan; Braun, David A; Rathi, Nityam; Thouvenin, Jonathan; Collier, Katharine A; Seront, Emmanuel; de Velasco, Guillermo; Dzimitrowicz, Hannah; Beuselinck, Benoit; Xu, Wenxin; Bowman, I Alex; Lam, Elaine T; Abuqayas, Bashar; Bilen, Mehmet Asim; Varkaris, Andreas; Zakharia, Yousef; Harrison, Michael R; Mortazavi, Amir; Barthélémy, Philippe; Agarwal, Neeraj; McKay, Rana R; Brastianos, Priscilla K; Krajewski, Katherine M; Albigès, Laurence; Harshman, Lauren C; Choueiri, Toni K

Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer

靶向内在凋亡通路:前列腺癌治疗的契机

Westaby, Daniel; Jimenez-Vacas, Juan M; Padilha, Ana; Varkaris, Andreas; Balk, Steven P; de Bono, Johann S; Sharp, Adam

Small cell transformation of non-small cell lung cancer on immune checkpoint inhibitors: uncommon or under-recognized?

免疫检查点抑制剂治疗下非小细胞肺癌的小细胞转化:罕见还是未被充分认识?

Sehgal, Kartik; Varkaris, Andreas; Viray, Hollis; VanderLaan, Paul A; Rangachari, Deepa; Costa, Daniel B