日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation

C-降解子通过维持非活性Chk1的稳定性并使其在激活后迅速消退来调控Chk1激酶。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2605594123
Oh, Jang-Hyun; Hyun, Ju-Yeon; Chen, Shun-Jia; Varshavsky, Alexander
信号转导
发表日期：2026
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N-degron pathways

N-降解途径

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2408697121
Varshavsky, Alexander
发表日期：2024
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Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system

迪特·沃尔夫（1941–2023）：毕生致力于理解蛋白质质量控制和泛素-蛋白酶体系统。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms24098292
Kaplan, Mohammed; Yao, Qing; Jensen, Grant J; Varshavsky, Alexander; Finley, Daniel; Goldberg, Alfred L; Rapoport, Tom A; Pfirrmann, Thorsten
发表日期：2023
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Deletions of DNA in cancer and their possible uses for therapy

癌症中DNA的缺失及其在治疗中的潜在用途

期刊:Bioessays
影响因子:2.7
doi:10.1002/bies.202300051
Varshavsky, Alexander; Lewis, Kim; Chen, Shun-Jia
肿瘤
肿瘤免疫
发表日期：2023
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Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates

Ate1精氨酰-tRNA-蛋白转移酶的晶体结构及N-降解子底物的精氨酰化

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2209597119
Kim, Bong Heon; Kim, Min Kyung; Oh, Sun Joo; Nguyen, Kha The; Kim, Jun Hoe; Varshavsky, Alexander; Hwang, Cheol-Sang; Song, Hyun Kyu
发表日期：2022
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Lymphocyte Exhaustion in AML Patients and Impacts of HMA/Venetoclax or Intensive Chemotherapy on Their Biology

AML 患者的淋巴细胞衰竭以及 HMA/Venetoclax 或强化化疗对其生物学的影响

期刊:Cancers
影响因子:
doi:10.3390/cancers14143352
Dmitry Zhigarev, Asya Varshavsky, Alexander W MacFarlane 4th, Prathiba Jayaguru, Laura Barreyro, Marina Khoreva, Essel Dulaimi, Reza Nejati, Christina Drenberg, Kerry S Campbell
免疫
细胞生物学
其它细胞
发表日期：2022
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Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway

氨肽酶修饰 Xaa-Pro 蛋白，启动其通过 Pro/N-降解途径的降解。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2115430118
Chen, Shun-Jia; Kim, Leehyeon; Song, Hyun Kyu; Varshavsky, Alexander
发表日期：2021
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Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling

Arg/N-降解途径的五种酶形成靶向复合物：超通道的概念

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2003043117
Oh, Jang-Hyun; Hyun, Ju-Yeon; Chen, Shun-Jia; Varshavsky, Alexander
发表日期：2020
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The Arg/N-degron pathway targets transcription factors and regulates specific genes

Arg/N-降解子通路靶向转录因子并调控特定基因

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2020124117
Vu, Tri T M; Mitchell, Dylan C; Gygi, Steven P; Varshavsky, Alexander
信号转导
发表日期：2020
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Evolution of Substrates and Components of the Pro/N-Degron Pathway.

Pro/N-降解途径的底物和组分的演变

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.9b00953
Chen Shun-Jia, Melnykov Artem, Varshavsky Alexander
发表日期：2020
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