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日期影响因子

G1405 Ribosomal Methyltransferase-Driven Antibacterial Resistance Affects the 4,5-Disubstituted-2-deoxystreptamine Class of Aminoglycoside Antibiotics

G1405 核糖体甲基转移酶驱动的抗菌耐药性影响 4,5-二取代-2-脱氧链霉胺类氨基糖苷类抗生素

影响因子:8.7

doi:10.1021/jacsau.5c01358

Hobbie, Sven N; Vasella, Andrea; Böttger, Erik C; Crich, David

发表日期：2026

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Synthesis of Methyl Aprabiosaminide and 2-Hydroxyapramycin from Apramycin

由阿普拉霉素合成甲基阿普拉比索胺和2-羟基阿普拉霉素

期刊:Organic Letters

doi:10.1021/acs.orglett.5c00168

Kasdekar, Niteshlal; Spieker, Michael R; Vasella, Andrea; Hobbie, Sven N; Crich, David

发表日期：2025

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Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2

庆大霉素C1、C2和C2a的合成以及庆大霉素B1、C1、C1a、C2、C2a、C2b和X2的抗核糖体和抗菌活性

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.3c00233

Jana, Santanu; Rajasekaran, Parasuraman; Haldimann, Klara; Vasella, Andrea; Böttger, Erik C; Hobbie, Sven N; Crich, David

发表日期：2023

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Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction

阿普拉霉素-核糖体解码A位点相互作用中协同氢键的重要性

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202200486

Pirrone, Michael G; Ande, Chennaiah; Haldimann, Klara; Hobbie, Sven N; Vasella, Andrea; Böttger, Erik C; Crich, David

发表日期：2023

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Synthesis of 4-O-(4-Amino-4-deoxy-β-D-xylopyranosyl)paromomycin and 4-S-(β-D-Xylopyranosyl)-4-deoxy-4'-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity

4-O-(4-氨基-4-脱氧-β-D-木糖吡喃糖基)巴龙霉素和4-S-(β-D-木糖吡喃糖基)-4-脱氧-4'-硫代巴龙霉素的合成及其抗核糖体和抗菌活性评价

期刊:Tetrahedron

影响因子:2.2

doi:10.1016/j.tet.2023.133330

Mohamad-Ramshan, Rukshana; Ande, Chennaiah; Matsushita, Takahiko; Haldimann, Klara; Vasella, Andrea; Hobbie, Sven N; Crich, David

发表日期：2023

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Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics

4,5-氨基糖苷类抗生素5''位修饰的构效关系

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202200120

Quirke, Jonathan C K; Sati, Girish C; Sonousi, Amr; Gysin, Marina; Haldimann, Klara; Böttger, Erik C; Vasella, Andrea; Hobbie, Sven N; Crich, David

发表日期：2022

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Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes.

为克服氨基糖苷修饰酶引起的耐药性，合成了在 5''- 和其他位置功能化的丙吡霉素衍生物及其抗菌活性

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.1c00158

Lubriks Dimitrijs, Zogota Rimants, Sarpe Vikram A, Matsushita Takahiko, Sati Girish C, Haldimann Klara, Gysin Marina, BÃ¶ttger Erik C, Vasella Andrea, Suna Edgars, Hobbie Sven N, Crich David

发表日期：2021

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Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity

构象受限的巴龙霉素I环类似物中环大小对核糖体和抗菌活性的影响

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d1md00214g

Pirrone, Michael G; Hobbie, Sven N; Vasella, Andrea; Böttger, Erik C; Crich, David

发表日期：2021

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An Advanced Apralog with Increased inâ vitro and inâ vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.

一种先进的Apralog，对革兰氏阴性病原体具有更高的体外和体内活性，并降低了离体耳蜗毒性

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202000726

Sonousi Amr, Quirke Jonathan C K, Waduge Prabuddha, Janusic Tanja, Gysin Marina, Haldimann Klara, Xu Shan, Hobbie Sven N, Sha Su-Hua, Schacht Jochen, Chow Christine S, Vasella Andrea, BÃ¶ttger Erik C, Crich David

发表日期：2021

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Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.

Apralogs：Apramycin 5-O-糖苷和醚，具有改进的抗菌活性和核糖体选择性，并降低了对氨酰转移酶（3）-IV 耐药决定簇的敏感性

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.9b11601

Quirke Jonathan C K, Rajasekaran Parasuraman, Sarpe Vikram A, Sonousi Amr, Osinnii Ivan, Gysin Marina, Haldimann Klara, Fang Qiao-Jun, Shcherbakov Dimitri, Hobbie Sven N, Sha Su-Hua, Schacht Jochen, Vasella Andrea, BÃ¶ttger Erik C, Crich David

发表日期：2020

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