日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models

左乙拉西坦通过SV2a依赖性调节APP加工来抑制阿尔茨海默病模型中Aβ的产生。

Rao, Nalini R; Santiago-Marrero, Ivan; DeGulis, Olivia; Nomura, Toshihiro; Goyal, Kritika; Lee, SeungEun; Hark, Timothy J; Dynes, Justin C; Dexter, Emily X; Dulewicz, Maciej; Ge, Junyue; Upadhyay, Arun; Fornasiero, Eugenio F; Vassar, Robert; Hanrieder, Jörg; Contractor, Anis; Savas, Jeffrey N

Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.

与阿尔茨海默病相关的 ACE 变体增加 ACE1 催化活性和血管紧张素 II 的产生。

Salvo Miranda A, Cuddy Leah K, Prokopenko Dmitry, Watkins Elyse, Tanzi Rudolph E, Vassar Robert

Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice.

神经元中 Nrf2 的过度表达可减少 5XFAD 阿尔茨海默病模型小鼠的营养不良性神经突。

Sadleir Katherine R, Gomez Karen P, Chandra Sidhanth, Ley Makenna L, Khatri Ammaarah W, Guo Joanna, Xue Yunlu, Cepko Constance L, Vassar Robert

Author Correction: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease

作者更正:小胶质细胞机制驱动阿尔茨海默病免疫患者体内β-淀粉样蛋白的清除

van Olst, Lynn; Simonton, Brooke; Edwards, Alex J; Forsyth, Anne V; Boles, Jake; Jamshidi, Pouya; Watson, Thomas; Shepard, Nate; Krainc, Talia; Argue, Benney Mr; Zhang, Ziyang; Kuruvilla, Joshua; Camp, Lily; Li, Mengwei; Xu, Hang; Norman, Jeanette L; Cahan, Joshua; Vassar, Robert; Chen, Jinmiao; Castellani, Rudolph J; Nicoll, James Ar; Boche, Delphine; Gate, David

The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.

与阿尔茨海默病相关的 UNC5C T835M 突变会导致老年小鼠出现涉及氧化应激和海马萎缩的神经退行性变

Karunakaran Devi Krishna Priya, Ley Makenna, Guo Joanna, Khatri Ammaarah, Sadleir Katherine, Popovic Jelena, Upadhyay Arun Kumar, Savas Jeffrey, Procissi Daniele, Atwal Jasvinder, Vassar Robert

Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains.

腹侧前脑祖细胞的单细胞转录组学研究发现,Evf2 增强子 lncRNA 增强子基因通过直接 RNA 结合和 RNP 募集结构域进行引导

Li Edward, Chakraborty Abhijit, Kohtz Sara J, Cajigas Ivelisse, Hinojosa-Gonzalez Laura, Shiau Fion, Bertossi Ryan, Vassar Robert J, Kessler Jack A, Ay Ferhat, Clark Brian S, Kohtz Jhumku D

The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17.

肠道微生物群通过丙酸介导的IL-17调节来控制Aβ淀粉样变性期间的反应性星形胶质细胞增生

Chandra Sidhanth, Popovic Jelena, Singhal Naveen K, Watkins Elyse A, Dodiya Hemraj B, Weigle Ian Q, Salvo Miranda A, Ramakrishnan Abhirami, Chen Zhangying, Watson Thomas, Shetti Aashutosh, Piehl Natalie, Zhang Xiaoqiong, Cuddy Leah, Sadleir Katherine R, Schwulst Steven J, Prakriya Murali, Gate David, Sisodia Sangram S, Vassar Robert

X-chromosome-wide association study for Alzheimer's disease

阿尔茨海默病X染色体全关联研究

Le Borgne, Julie; Gomez, Lissette; Heikkinen, Sami; Amin, Najaf; Ahmad, Shahzad; Choi, Seung Hoan; Bis, Joshua; Grenier-Boley, Benjamin; Rodriguez, Omar Garcia; Kleineidam, Luca; Young, Juan; Tripathi, Kumar Parijat; Wang, Lily; Varma, Achintya; Campos-Martin, Rafael; van der Lee, Sven; Damotte, Vincent; de Rojas, Itziar; Palmal, Sagnik; Lipton, Richard; Reiman, Eric; McKee, Ann; De Jager, Philip; Bush, William; Small, Scott; Levey, Allan; Saykin, Andrew; Foroud, Tatiana; Albert, Marilyn; Hyman, Bradley; Petersen, Ronald; Younkin, Steven; Sano, Mary; Wisniewski, Thomas; Vassar, Robert; Schneider, Julie; Henderson, Victor; Roberson, Erik; DeCarli, Charles; LaFerla, Frank; Brewer, James; Swerdlow, Russell; Van Eldik, Linda; Hamilton-Nelson, Kara; Paulson, Henry; Naj, Adam; Lopez, Oscar; Chui, Helena; Crane, Paul; Grabowski, Thomas; Kukull, Walter; Asthana, Sanjay; Craft, Suzanne; Strittmatter, Stephen; Cruchaga, Carlos; Leverenz, James; Goate, Alison; Kamboh, M Ilyas; George-Hyslop, Peter St; Valladares, Otto; Kuzma, Amanda; Cantwell, Laura; Riemenschneider, Matthias; Morris, John; Slifer, Susan; Dalmasso, Carolina; Castillo, Atahualpa; Küçükali, Fahri; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Pastor, Pau; Sánchez-Valle, Raquel; Álvarez, Victoria; Boada, Mercè; García-González, Pablo; Puerta, Raquel; Mir, Pablo; Real, Luis M; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Royo, Jose Luís; Rodriguez-Rodriguez, Eloy; Soininen, Hilkka; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Thomassen, Jesper Qvist; Pijnenburg, Yolande A L; Holstege, Henne; van Swieten, John; Ramakers, Inez; Verhey, Frans; Scheltens, Philip; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Boland, Anne; Deleuze, Jean-François; Nicolas, Gael; Dufouil, Carole; Pasquier, Florence; Hanon, Olivier; Debette, Stéphanie; Grünblatt, Edna; Popp, Julius; Ghidoni, Roberta; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Solfrizzi, Vincenzo; Parnetti, Lucilla; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Nacmias, Benedetta; Spallazzi, Marco; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Bossù, Paola; Masullo, Carlo; Rossi, Giacomina; Jessen, Frank; Fernandez, Victoria; Kehoe, Patrick Gavin; Frikke-Schmidt, Ruth; Tsolaki, Magda; Sánchez-Juan, Pascual; Sleegers, Kristel; Ingelsson, Martin; Haines, Jonathan; Farrer, Lindsay; Mayeux, Richard; Wang, Li-San; Sims, Rebecca; DeStefano, Anita; Schellenberg, Gerard D; Seshadri, Sudha; Amouyel, Philippe; Williams, Julie; van der Flier, Wiesje; Ramirez, Alfredo; Pericak-Vance, Margaret; Andreassen, Ole A; Van Duijn, Cornelia; Hiltunen, Mikko; Ruiz, Agustín; Dupuis, Josée; Martin, Eden; Lambert, Jean-Charles; Kunkle, Brian; Bellenguez, Céline

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

一项包含56241名个体的多族裔全基因组荟萃分析,发现了已知的和新的跨人群及族裔特异性关联,这些关联被认为是阿尔茨海默病的新风险位点。

Rajabli, Farid; Benchek, Penelope; Tosto, Giuseppe; Kushch, Nicholas; Sha, Jin; Bazemore, Katrina; Zhu, Congcong; Lee, Wan-Ping; Haut, Jacob; Hamilton-Nelson, Kara L; Wheeler, Nicholas R; Zhao, Yi; Farrell, John J; Grunin, Michelle A; Leung, Yuk Yee; Kuksa, Pavel P; Li, Donghe; da Fonseca, Eder Lucio; Mez, Jesse B; Palmer, Ellen L; Pillai, Jagan; Sherva, Richard M; Song, Yeunjoo E; Zhang, Xiaoling; Ikeuchi, Takeshi; Iqbal, Taha; Pathak, Omkar; Valladares, Otto; Reyes-Dumeyer, Dolly; Kuzma, Amanda B; Abner, Erin; Adams, Larry D; Adams, Perrie M; Aguirre, Alyssa; Albert, Marilyn S; Albin, Roger L; Allen, Mariet; Alvarez, Lisa; Apostolova, Liana G; Arnold, Steven E; Asthana, Sanjay; Atwood, Craig S; Auerbach, Sanford; Ayres, Gayle; Baldwin, Clinton T; Barber, Robert C; Barnes, Lisa L; Barral, Sandra; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Benitez, Bruno A; Bennett, David; Bertelson, John; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Brewer, James; Burke, James R; Burns, Jeffrey M; Buxbaum, Joseph D; Cairns, Nigel J; Cantwell, Laura B; Cao, Chuanhai; Carlson, Christopher S; Carlsson, Cynthia M; Carney, Regina M; Carrasquillo, Minerva M; Chasse, Scott; Chesselet, Marie-Francoise; Chin, Nathaniel A; Chui, Helena C; Chung, Jaeyoon; Craft, Suzanne; Crane, Paul K; Cribbs, David H; Crocco, Elizabeth A; Cruchaga, Carlos; Cuccaro, Michael L; Cullum, Munro; Darby, Eveleen; Davis, Barbara; De Jager, Philip L; DeCarli, Charles; DeToledo, John; Dick, Malcolm; Dickson, Dennis W; Dombroski, Beth A; Doody, Rachelle S; Duara, Ranjan; Ertekin-Taner, NIlüfer; Evans, Denis A; Faber, Kelley M; Fairchild, Thomas J; Fallon, Kenneth B; Fardo, David W; Farlow, Martin R; Fernandez-Hernandez, Victoria; Ferris, Steven; Friedland, Robert P; Foroud, Tatiana M; Frosch, Matthew P; Fulton-Howard, Brian; Galasko, Douglas R; Gamboa, Adriana; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Go, Rodney C P; Goate, Alison M; Grabowski, Thomas J; Graff-Radford, Neill R; Green, Robert C; Growdon, John H; Hakonarson, Hakon; Hall, James; Hamilton, Ronald L; Harari, Oscar; Hardy, John; Harrell, Lindy E; Head, Elizabeth; Henderson, Victor W; Hernandez, Michelle; Hohman, Timothy; Honig, Lawrence S; Huebinger, Ryan M; Huentelman, Matthew J; Hulette, Christine M; Hyman, Bradley T; Hynan, Linda S; Ibanez, Laura; Jarvik, Gail P; Jayadev, Suman; Jin, Lee-Way; Johnson, Kim; Johnson, Leigh; Kamboh, M Ilyas; Karydas, Anna M; Katz, Mindy J; Kauwe, John S; Kaye, Jeffrey A; Keene, C Dirk; Khaleeq, Aisha; Kikuchi, Masataka; Kim, Ronald; Knebl, Janice; Kowall, Neil W; Kramer, Joel H; Kukull, Walter A; LaFerla, Frank M; Lah, James J; Larson, Eric B; Lerner, Alan; Leverenz, James B; Levey, Allan I; Lieberman, Andrew P; Lipton, Richard B; Logue, Mark; Lopez, Oscar L; Lunetta, Kathryn L; Lyketsos, Constantine G; Mains, Douglas; Margaret, Flanagan E; Marson, Daniel C; Martin, Eden Rr; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; Massman, Paul; Masurkar, Arjun; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McDonough, Stefan; McKee, Ann C; Mesulam, Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Monuki, Edwin S; Morris, John C; Mukherjee, Shubhabrata; Myers, Amanda J; Nguyen, Trung; Obisesan, Thomas; O'Bryant, Sid; Olichney, John M; Ory, Marcia; Palmer, Raymond; Parisi, Joseph E; Paulson, Henry L; Pavlik, Valory; Paydarfar, David; Perez, Victoria; Peskind, Elaine; Petersen, Ronald C; Petrovitch, Helen; Pierce, Aimee; Polk, Marsha; Poon, Wayne W; Potter, Huntington; Qu, Liming; Quiceno, Mary; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reisch, Joan S; Ringman, John M; Roberson, Erik D; Rodriguear, Monica; Rogaeva, Ekaterina; Rosen, Howard J; Rosenberg, Roger N; Royall, Donald R; Sabbagh, Marwan; Sadovnick, A Dessa; Sager, Mark A; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Slifer, Susan H; Small, Scott; Smith, Amanda G; Smith, Janet P; Sonnen, Joshua A; Spina, Salvatore; George-Hyslop, Peter St; Starks, Takiyah D; Stern, Robert A; Stevens, Alan B; Strittmatter, Stephen M; Sultzer, David; Swerdlow, Russell H; Tanzi, Rudolph E; Tilson, Jeffrey L; Trojanowski, John Q; Troncoso, Juan C; Tsolaki, Magda; Tsuang, Debby W; Van Deerlin, Vivianna M; van Eldik, Linda J; Vance, Jeffery M; Vardarajan, Badri N; Vassar, Robert; Vinters, Harry V; Vonsattel, Jean-Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Whitehead, Patrice L; Wijsman, Ellen M; Wilhelmsen, Kirk C; Williams, Benjamin; Williamson, Jennifer; Wilms, Henrik; Wingo, Thomas S; Wisniewski, Thomas; Woltjer, Randall L; Woon, Martin; Wright, Clinton B; Wu, Chuang-Kuo; Younkin, Steven G; Yu, Chang-En; Yu, Lei; Zhu, Xiongwei; Kunkle, Brian W; Bush, William S; Miyashita, Akinori; Byrd, Goldie S; Wang, Li-San; Farrer, Lindsay A; Haines, Jonathan L; Mayeux, Richard; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Jun, Gyungah R; Reitz, Christiane; Naj, Adam C

The Proteoform Landscape of Tau from the Human Brain

人脑中Tau蛋白的蛋白质异构体图谱

Xu, Tian; Su, Taojunfeng; Soye, Benjamin J Des; Kandi, Soumya; Huang, Che-Fan; Wilkins, John T; Castellani, Rudolph J; Kafader, Jared O; Patrie, Steven M; Vassar, Robert; Kelleher, Neil L