Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
BIIB129 的发现和临床前表征：一种共价、选择性且能穿透血脑屏障的 BTK 抑制剂，用于治疗多发性硬化症
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00220
Himmelbauer, Martin K; Bajrami, Bekim; Basile, Rebecca; Capacci, Andrew; Chen, TeYu; Choi, Colin K; Gilfillan, Rab; Gonzalez-Lopez de Turiso, Felix; Gu, Chungang; Hoemberger, Marc; Johnson, Douglas S; Jones, J Howard; Kadakia, Ekta; Kirkland, Melissa; Lin, Edward Y; Liu, Ying; Ma, Bin; Magee, Tom; Mantena, Srinivasa; Marx, Isaac E; Metrick, Claire M; Mingueneau, Michael; Murugan, Paramasivam; Muste, Cathy A; Nadella, Prasad; Nevalainen, Marta; Parker Harp, Chelsea R; Pattaropong, Vatee; Pietrasiewicz, Alicia; Prince, Robin J; Purgett, Thomas J; Santoro, Joseph C; Schulz, Jurgen; Sciabola, Simone; Tang, Hao; Vandeveer, H George; Wang, Ti; Yousaf, Zain; Helal, Christopher J; Hopkins, Brian T
