日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

一类新型共价抑制剂可阻断核苷酸与丙酮酸激酶活性位点的结合

Morgan Hugh P, Walsh Martin J, Blackburn Elizabeth A, Wear Martin A, Boxer Matthew B, Shen Min, Veith Henrike, McNae Iain W, Nowicki Matthew W, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

2-氧代-N-芳基-1,2,3,4-四氢喹啉-6-磺酰胺类化合物作为肿瘤细胞特异性丙酮酸激酶M2亚型的激活剂

Walsh, Martin J; Brimacombe, Kyle R; Veith, Henrike; Bougie, James M; Daniel, Thomas; Leister, William; Cantley, Lewis C; Israelsen, William J; Vander Heiden, Matthew G; Shen, Min; Auld, Douglas S; Thomas, Craig J; Boxer, Matthew B

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

评价噻吩并[3,2-b]吡咯并[3,2-d]哒嗪酮作为肿瘤细胞特异性丙酮酸激酶M2亚型激活剂的活性

Jiang, Jian-kang; Boxer, Matthew B; Vander Heiden, Matthew G; Shen, Min; Skoumbourdis, Amanda P; Southall, Noel; Veith, Henrike; Leister, William; Austin, Christopher P; Park, Hee Won; Inglese, James; Cantley, Lewis C; Auld, Douglas S; Thomas, Craig J

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

对化学库中细胞色素P450同工酶选择性的全面表征

Veith, Henrike; Southall, Noel; Huang, Ruili; James, Tim; Fayne, Darren; Artemenko, Natalia; Shen, Min; Inglese, James; Austin, Christopher P; Lloyd, David G; Auld, Douglas S