日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AI meets physics in computational structure-based drug discovery for GPCRs

人工智能与物理学在基于计算结构的GPCR药物发现中相遇

Michino, Mayako; Vendome, Jeremie; Kufareva, Irina

Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055

优化小分子ENL YEATS抑制剂以开展体内研究:TDI-11055的发现

Michino, Mayako; Khan, Tanweer A; Miller, Michael W; Fukase, Yoshiyuki; Vendome, Jeremie; Adura, Carolina; Glickman, J Fraser; Liu, Yiman; Wan, Liling; Allis, C David; Stamford, Andrew W; Meinke, Peter T; Renzetti, Louis M; Kargman, Stacia; Liverton, Nigel J; Huggins, David J

Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II

抗疟原虫蛋白酶体抑制剂的构效关系研究——第二部分

Zhang, Hao; Ginn, John; Zhan, Wenhu; Leung, Annie; Liu, Yi J; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Michino, Mayako; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Liverton, Nigel; Foley, Michael; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang

Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors

基于形状的虚拟筛选方法对包含十亿种化合物的化合物库进行筛选,鉴定出分枝杆菌硫辛酰胺脱氢酶抑制剂

Michino, Mayako; Beautrait, Alexandre; Boyles, Nicholas A; Nadupalli, Aparna; Dementiev, Alexey; Sun, Shan; Ginn, John; Baxt, Leigh; Suto, Robert; Bryk, Ruslana; Jerome, Steven V; Huggins, David J; Vendome, Jeremie

Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors

大环肽作为物种选择性抗疟蛋白酶体抑制剂的设计、合成和优化

Hao Zhang, John Ginn, Wenhu Zhan, Yi J Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T Meinke, Carl F Nathan, Laura A Kirkman, Gang Lin

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

早期出现哌喹耐药性恶性疟原虫的证据及缓解耐药性的建模策略

Small-Saunders, Jennifer L; Hagenah, Laura M; Wicht, Kathryn J; Dhingra, Satish K; Deni, Ioanna; Kim, Jonathan; Vendome, Jeremie; Gil-Iturbe, Eva; Roepe, Paul D; Mehta, Monica; Mancia, Filippo; Quick, Matthias; Eppstein, Margaret J; Fidock, David A

Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice

在人源化小鼠中开发具有抗疟活性的高选择性恶性疟原虫蛋白酶体抑制剂

Zhan, Wenhu; Zhang, Hao; Ginn, John; Leung, Annie; Liu, Yi J; Michino, Mayako; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Lafuente-Monasterio, Maria Jose; Martinez-Martinez, Maria Santos; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang

Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome

选择性抑制结核分枝杆菌蛋白酶体的大环肽

Hao Zhang, Hao-Chi Hsu, Shoshanna C Kahne, Ryoma Hara, Wenhu Zhan, Xiuju Jiang, Kristin Burns-Huang, Tierra Ouellette, Toshihiro Imaeda, Rei Okamoto, Masanori Kawasaki, Mayako Michino, Tzu-Tshin Wong, Akinori Toita, Takafumi Yukawa, Francesca Moraca, Jeremie Vendome, Priya Saha, Kenjiro Sato, Kazuyo

Fine Sampling of Sequence Space for Membrane Protein Structural Biology

膜蛋白结构生物学序列空间的精细采样

Michael Loukeris, Zahra Assur Sanghai, Jeremie Vendome, Wayne A Hendrickson, Brian Kloss, Filippo Mancia

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

恶性疟原虫转运蛋白 PfCRT 的结构和耐药性

Jonathan Kim #,Yong Zi Tan #,Kathryn J Wicht,Satchal K Erramilli,Satish K Dhingra,John Okombo,Jeremie Vendome,Laura M Hagenah,Sabrina I Giacometti,Audrey L Warren,Kamil Nosol,Paul D Roepe,Clinton S Potter,Bridget Carragher,Anthony A Kossiakoff,Matthias Quick,David A Fidock,Filippo Mancia