日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural defects in amyloid-β fibrils drive secondary nucleation

淀粉样β纤维的结构缺陷驱动二级成核

Hu, Jing; Scheidt, Tom; Thacker, Dev; Axell, Emil; Stemme, Elin; Łapińska, Urszula; Wennmalm, Stefan; Meisl, Georg; Curk, Samo; Andreasen, Maria; Vendruscolo, Michele; Arosio, Paolo; Šarić, Anđela; Schmit, Jeremy D; Knowles, Tuomas P J; Sparr, Emma; Linse, Sara; Michaels, Thomas C T; Dear, Alexander J

Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay"

对“利用迭代机器学习和多晶型特异性脑种子纤维扩增分析设计Tau蛋白聚集抑制剂”一文的更正

Santambrogio, Alessia; Horne, Robert I; Metrick, Michael A 2nd; Gallagher, Nicholas C T; Brotzakis, Z Faidon; Rinauro, Dillon; Vourkou, Ergina; Papanikolopoulou, Katerina; Skoulakis, Efthimios M C; Linse, Sara; Caughey, Byron; Vendruscolo, Michele

Classification of tauopathies from human brain homogenates through salt-modulated tau amplification

通过盐调节的tau蛋白扩增对人脑匀浆中的tau蛋白病进行分类

Santambrogio, Alessia; Metrick, Michael A 2nd; Xu, Peifeng; Gallagher, Nicholas C T; Koga, Shunsuke; Ghetti, Bernardino; Dickson, Dennis W; Caughey, Byron; Vendruscolo, Michele

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles

追踪人类iPSC-小胶质细胞中的tau蛋白和细胞反应:从摄取到可播种分泌,包括在细胞外囊泡中

Karabova, Maria Kreger; Del Ser-Badia, Anna; Hedegaard, Anne; Washer, Sam J; Baykam, Zeynep; O'Brien, Darragh P; Vendrell, Iolanda; Hester, Svenja S; Fischer, Roman; Johnson, Errin; Melia, Charlotte E; Matthews-Palmer, Teige R S; Matadeen, Rishi; Santambrogio, Alessia; Metrick, Michael A 2nd; Vendruscolo, Michele; Keeling, Sophie; Cheam, Kimberly Ai Xian; McEwan, William A; Kosik, Kenneth S; Day, Theresa A; James, William S; Cowley, Sally A

The α-synuclein proteostasis network and its translational applications in Parkinson's disease

α-突触核蛋白稳态网络及其在帕金森病中的转化应用

Lim, Christine M; Vendruscolo, Michele

Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking.

利用深度对接技术从超大型化学库中鉴定出Aβ42聚集的强效高亲和力二级成核抑制剂。

Brezinova Michaela, Brotzakis Z Faidon, Horne Robert I, Roy Chowdhury Vaidehi, Gregory Rebecca C, Bian Yuqi, González Díaz Alicia, Gentile Francesco, Vendruscolo Michele

Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds

利用合理设计的抗体样支架对2型糖尿病血清中IAPP小聚集体进行单分子成像

Lin, Jiacheng; Zhang, Yu P; Chia, Sean; Klenerman, David; Sormanni, Pietro; Vendruscolo, Michele

Ca(2+)-driven PDIA6 biomolecular condensation ensures proinsulin folding.

Ca(2+)驱动的PDIA6生物分子缩合确保胰岛素原折叠。

Lee Young-Ho, Saio Tomohide, Watabe Mai, Matsusaki Motonori, Kanemura Shingo, Lin Yuxi, Mannen Taro, Kuramochi Tsubura, Kamada Yuka, Iuchi Katsuya, Tajiri Michiko, Suzuki Kotono, Li Yan, Heo Yunseok, Ishii Kotone, Arai Kenta, Ban Kazunori, Hashimoto Mayuko, Oshita Shuichiro, Ninagawa Satoshi, Hattori Yoshikazu, Kumeta Hiroyuki, Takeuchi Airu, Kajimoto Shinji, Abe Hiroya, Mori Eiichiro, Muraoka Takahiro, Nakabayashi Takakazu, Akashi Satoko, Okiyoneda Tsukasa, Vendruscolo Michele, Inaba Kenji, Okumura Masaki

AlphaFold prediction of structural ensembles of disordered proteins

AlphaFold对无序蛋白质结构集合的预测

Brotzakis, Z Faidon; Zhang, Shengyu; Murtada, Mhd Hussein; Vendruscolo, Michele

Sequence-based virtual screening using transformers

基于序列的虚拟筛选(使用Transformer)

Zhang, Shengyu; Huo, Donghui; Horne, Robert I; Qi, Yumeng; Pujalte Ojeda, Sebastian; Yan, Aixia; Vendruscolo, Michele