日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

Sotorasib 修饰的 KRAS G12C-MHC I 复合物的治疗靶向性和结构表征证明了基于半抗原的策略的抗肿瘤功效

Apurva Pandey #, Peter J Rohweder #, Lieza M Chan #, Chayanid Ongpipattanakul, Dong Hee Chung, Bryce Paolella, Fiona M Quimby, Ngoc Nguyen, Kliment A Verba, Michael J Evans, Charles S Craik

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection

衣原体效应蛋白Dre1与动力蛋白结合,在感染过程中重新定位宿主细胞器。

Jessica Sherry,Komal Ishwar Pawar,Lee Dolat,Erin Smith,I-Chang Chang,Khavong Pha,Robyn Kaake,Danielle L Swaney,Clara Herrera,Eleanor McMahon,Robert J Bastidas,Jeffrey R Johnson,Raphael H Valdivia,Nevan J Krogan,Cherilyn A Elwell,Kliment Verba,Joanne N Engel

Recognizing amino acid sidechains in a medium-resolution cryo-electron density map

在中等分辨率冷冻电镜密度图中识别氨基酸侧链

Mondal, Dibyendu; Kumar, Vipul; Satler, Tadej; Ramachandran, Rakesh; Saltzberg, Daniel; Chemmama, Ilan; Pilla, Kala Bharath; Echeverria, Ignacia; Webb, Benjamin M; Gupta, Meghna; Verba, Klim; Sali, Andrej

Human cooperation with artificial agents varies across countries

人类与人工智能体的合作方式因国家而异。

Karpus, Jurgis; Shirai, Risako; Verba, Julia Tovar; Schulte, Rickmer; Weigert, Maximilian; Bahrami, Bahador; Watanabe, Katsumi; Deroy, Ophelia

Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation

PI3Kα/KRas复合物在脂质双层上的结构揭示了PI3Kα激活的分子机制。

Torosyan, Hayarpi; Paul, Michael D; Maker, Allison; Meyer, Brigitte G; Jura, Natalia; Verba, Kliment A

Recognizing amino acid sidechains in a medium resolution cryo-electron density map

在中等分辨率冷冻电镜密度图中识别氨基酸侧链

Mondal, Dibyendu; Kumar, Vipul; Satler, Tadej; Ramachandran, Rakesh; Saltzberg, Daniel; Chemmama, Ilan; Pilla, Kala Bharath; Echeverria, Ignacia; Webb, Benjamin M; Gupta, Meghna; Verba, Klim; Sali, Andrej

Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial

一项来自随机对照 CONSUL 试验的研究比较了在放射学确诊为中轴型脊柱关节炎的患者中,抗 TNF 疗法联合非甾体抗炎药治疗与单独使用抗 TNF 疗法治疗 2 年内脊柱结构损伤进展情况。

Proft, Fabian; Torgutalp, Murat; Muche, Burkhard; Rios Rodriguez, Valeria; Listing, Joachim; Protopopov, Mikhail; Rademacher, Judith; Haibel, Hildrun; Spiller, Laura; Weber, Anne-Katrin; Verba, Maryna; Brandt-Juergens, Jan; Kiltz, Uta; Sieburg, Maren; Jacki, Swen; Sieper, Joachim; Poddubnyy, Denis

Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4

抗体发现确定了蛋白质精氨酸脱亚胺酶 4 的调节机制

Xin Zhou #, Sophie Kong #, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells