文献库，生知库 | 链接生命科学的每一步

Martinello, Chiara; Verhoeyen, Els; Grunblatt, Eli; Alkhalili, Sawsan A; Meng, Zhiying; Baldridge, Abigail S; Dinner, Shira; Gordon, Leo I; Mehta, Jayesh; Rao, Anjali; Singhal, Seema; Karmali, Reem; Akhter, Nausheen

免疫/内分泌

细胞生物学

T细胞

发表日期：2026

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Engineering Bi-Specific CAR-NK Cells to Restore Antibody-Dependent Cellular Cytotoxicity in Solid Tumors

工程改造双特异性CAR-NK细胞以恢复实体瘤中抗体依赖性细胞毒性

期刊:Cells

影响因子:5.2

doi:10.3390/cells15040373

Chung, Jee Young; Kim, Jung Eun; Cha, Daseuri; Lee, Hye Jin; Verhoeyen, Els; An, Hee Jung; Park, Jung Eun

Baboon endogenous retrovirus (ERV) envelope pseudotyped lentiviral vectors outperform human ERV lentivectors for transduction of T, B, NK and HSPCs

狒狒内源性逆转录病毒（ERV）包膜假型慢病毒载体在T细胞、B细胞、NK细胞和造血干细胞的转导方面优于人类ERV慢病毒载体。

期刊:Gene Therapy

影响因子:4.5

doi:10.1038/s41434-025-00587-w

Périan, Séverine; Castellano, Eva; Costa, Caroline; Martinello, Chiara; Galy, Anne; Froment, Gisèle; Orentas, Rimas; Valeri, Antonio; Verhoeyen, Els

Scavenging Reactive Oxygen Species by Cerium Oxide Nanoparticles Prevents Death in a Peripheral T Cell Lymphoma Preclinical Mouse Model

利用氧化铈纳米颗粒清除活性氧可预防外周T细胞淋巴瘤临床前小鼠模型中的细胞死亡

期刊:ACS Nano

影响因子:16

doi:10.1021/acsnano.5c02860

Krug, Adrien; Ernst, Lena M; Mhaidly, Rana; Ramis, Joana; Gusta, Muriel F; Bastus, Neus G; Martinez-Turtos, Adriana; Tosolini, Marie; Di Mascio, Léa; Tari, Gamze; Boyer, Laurent; Gaulard, Philippe; Lemonnier, François; Ricci, Jean-Ehrland; Verhoeyen, Els; Puntes, Victor

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins

胱氨酸病肌病同源人成肌细胞模型揭示关键肌源性调节蛋白的改变

期刊:Journal of Cachexia Sarcopenia and Muscle

影响因子:9.1

doi:10.1002/jcsm.70116

Medaer, Louise; Mora, Roger; Zhou, Zhuoheng; Giarratana, Nefele; Yedigaryan, Laura; La Rovere, Rita; Levtchenko, Elena; Mouly, Vincent; Verhoeyen, Els; Eeltink, Sebastiaan; Treumann, Achim; Vervliet, Tim; Sampaolesi, Maurilio; Gijsbers, Rik

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

ATP柠檬酸裂解酶是T细胞急性淋巴细胞白血病（T-ALL）发展过程中PTEN缺失诱导的代谢重编程中的关键参与者。

期刊:Blood Advances

影响因子:7.1

doi:10.1182/bloodadvances.2024013762

Andrieu, Guillaume P; Hypolite, Guillaume; Latiri, Mehdi; Balducci, Estelle; Costa, Caroline; Verhoeyen, Els; Courgeon, Marianne; Allatif, Omran; Nemazanyy, Ivan; Panasyuk, Ganna; Wellen, Kathryn; Herranz, Daniel; Genestier, Laurent; Macintyre, Elizabeth; Asnaﬁ, Vahid; Tesio, Melania

Ligand-modified rAAV6 vectors with nanoblades allow high-level gene knockin in HSPCs without compromising cell survival

带有纳米刀片的配体修饰的rAAV6载体可在不影响细胞存活率的情况下，实现造血干细胞（HSPC）中的高水平基因敲入。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2025.102495

Gutierrez-Guerrero, Alejandra; Périan, Séverine; Leray, Aurélien; Martinello, Chiara; Abrey Recalde, Maria Jimena; Costa, Caroline; Herrero, Cecilia Iglesias; Bouzelha, Mohammed; Alvarez-Dorta, Dimitri; Gouin, Sébastien G; Ayuso, Eduard; Adjali, Oumeya; Büning, Hildegard; Deniaud, David; Mével, Mathieu; Verhoeyen, Els

Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications

利用狒狒包膜假型慢病毒载体转导γδ T细胞，该载体编码嵌合抗原受体，用于转化和临床应用。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2025.1548630

Pinot, Lorraine; Saßor, Aylin; Möker, Nina; Zhang, Congcong; Verhoeyen, Els; Hidalgo, José Villacorta; Orentas, Rimas J

HLF and hTERT cooperatively enable partial immortalization of human hematopoietic stem and progenitor cells

HLF和hTERT协同作用，使人类造血干细胞和祖细胞部分永生化。

期刊:Frontiers in Bioengineering and Biotechnology

影响因子:4.8

doi:10.3389/fbioe.2025.1731355

Azhagiri, Manoj Kumar K; Verhoeyen, Els; Mohankumar, Kumarasamypet Murugesan; Marepally, Srujan Kumar; Venkatesan, Vigneshwaran; Thangavel, Saravanabhavan

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia

IKAROS基因调控网络揭示ERG是B细胞急性淋巴细胞白血病的一个脆弱点

期刊:

影响因子:

doi:10.64898/2025.12.29.696402

Paculova, Hana; Richman, Alyssa; Boyd, Joseph; Bernil, Joshua Carlos; Rodriguez, Princess; Ayongaba, Etapong; Ghule, Prachi; Drivet, Elsa; Palaria, Amrita; Dajani, Mariam; Verhoeyen, Els; Saviola, Anthony; Stein, Gary S; Schjerven, Hilde; Frietze, Seth

Cardiovascular Adverse Events Following Bispecific T-Cell Redirecting Antibody Therapy

双特异性T细胞重定向抗体治疗后心血管不良事件

Engineering Bi-Specific CAR-NK Cells to Restore Antibody-Dependent Cellular Cytotoxicity in Solid Tumors

工程改造双特异性CAR-NK细胞以恢复实体瘤中抗体依赖性细胞毒性

Baboon endogenous retrovirus (ERV) envelope pseudotyped lentiviral vectors outperform human ERV lentivectors for transduction of T, B, NK and HSPCs

狒狒内源性逆转录病毒（ERV）包膜假型慢病毒载体在T细胞、B细胞、NK细胞和造血干细胞的转导方面优于人类ERV慢病毒载体。

Scavenging Reactive Oxygen Species by Cerium Oxide Nanoparticles Prevents Death in a Peripheral T Cell Lymphoma Preclinical Mouse Model

利用氧化铈纳米颗粒清除活性氧可预防外周T细胞淋巴瘤临床前小鼠模型中的细胞死亡

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins

胱氨酸病肌病同源人成肌细胞模型揭示关键肌源性调节蛋白的改变

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

ATP柠檬酸裂解酶是T细胞急性淋巴细胞白血病（T-ALL）发展过程中PTEN缺失诱导的代谢重编程中的关键参与者。

Ligand-modified rAAV6 vectors with nanoblades allow high-level gene knockin in HSPCs without compromising cell survival

带有纳米刀片的配体修饰的rAAV6载体可在不影响细胞存活率的情况下，实现造血干细胞（HSPC）中的高水平基因敲入。

Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications

利用狒狒包膜假型慢病毒载体转导γδ T细胞，该载体编码嵌合抗原受体，用于转化和临床应用。

HLF and hTERT cooperatively enable partial immortalization of human hematopoietic stem and progenitor cells

HLF和hTERT协同作用，使人类造血干细胞和祖细胞部分永生化。

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia

IKAROS基因调控网络揭示ERG是B细胞急性淋巴细胞白血病的一个脆弱点