Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage
甲型流感病毒宿主转移后的长期适应导致宿主内病毒适应性增强,这是因为病毒复制率更高、在呼吸道上皮内传播更广泛、组织损伤减少
期刊:PLoS Pathogens
影响因子:5.5
doi:10.1371/journal.ppat.1010174
Julien A R Amat, Veronica Patton, Caroline Chauché, Daniel Goldfarb, Joanna Crispell, Quan Gu, Alice M Coburn, Gaelle Gonzalez, Daniel Mair, Lily Tong, Luis Martinez-Sobrido, John F Marshall, Francesco Marchesi, Pablo R Murcia