日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells

视黄酸通过抑制 AML 细胞中的 Nrf2 活性来增强 ATO 介导的细胞毒性

M Valenzuela, C Glorieux, J Stockis, B Sid, J M Sandoval, K B Felipe, M R Kviecinski, J Verrax, P Buc Calderon

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

肠道微生物衍生的丙酸盐可减少肝脏中的癌细胞增殖

L B Bindels, P Porporato, E M Dewulf, J Verrax, A M Neyrinck, J C Martin, K P Scott, P Buc Calderon, O Feron, G G Muccioli, P Sonveaux, P D Cani, N M Delzenne

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

靶向内皮细胞中的乳酸转运蛋白 MCT1 可抑制乳酸诱导的 HIF-1 活化和肿瘤血管生成

Pierre Sonveaux, Tamara Copetti, Christophe J De Saedeleer, Frédérique Végran, Julien Verrax, Kelly M Kennedy, Eui Jung Moon, Suveera Dhup, Pierre Danhier, Françoise Frérart, Bernard Gallez, Anthony Ribeiro, Carine Michiels, Mark W Dewhirst, Olivier Feron

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

乳酸在氧化型人类肿瘤细胞中激活HIF-1,但在Warburg表型人类肿瘤细胞中则不激活。

De Saedeleer, Christophe J; Copetti, Tamara; Porporato, Paolo E; Verrax, Julien; Feron, Olivier; Sonveaux, Pierre

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif

Hsp90 在高度保守的 N 端氨基酸基序处被活性氧切割。

Beck, Raphaël; Dejeans, Nicolas; Glorieux, Christophe; Creton, Mélanie; Delaive, Edouard; Dieu, Marc; Raes, Martine; Levêque, Philippe; Gallez, Bernard; Depuydt, Matthieu; Collet, Jean-François; Calderon, Pedro Buc; Verrax, Julien

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

靶向乳酸驱动的呼吸作用可选择性地杀死小鼠体内的乏氧肿瘤细胞。

Sonveaux, Pierre; Végran, Frédérique; Schroeder, Thies; Wergin, Melanie C; Verrax, Julien; Rabbani, Zahid N; De Saedeleer, Christophe J; Kennedy, Kelly M; Diepart, Caroline; Jordan, Bénédicte F; Kelley, Michael J; Gallez, Bernard; Wahl, Miriam L; Feron, Olivier; Dewhirst, Mark W