日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Improved epigenetic age prediction models by combining sex chromosome and autosomal markers

通过结合性染色体和常染色体标记改进表观遗传年龄预测模型

Wan, Zhong; Henneman, Peter; Hoefsloot, Huub C J; Kloosterman, Ate D; Verschure, Pernette J

Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer

时间分辨分析揭示ATF3是乳腺癌内分泌耐药性的新型介质

Borgoni, Simone; Sofyalı, Emre; Soleimani, Maryam; Wilhelm, Heike; Müller-Decker, Karin; Will, Rainer; Noronha, Ashish; Beumers, Lukas; Verschure, Pernette J; Yarden, Yosef; Magnani, Luca; van Kampen, Antoine H C; Moerland, Perry D; Wiemann, Stefan

Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer

与ER+/HER2-乳腺癌内分泌治疗耐药相关的候选甲基化位点

Soleimani Dodaran, Maryam; Borgoni, Simone; Sofyalı, Emre; Verschure, Pernette J; Wiemann, Stefan; Moerland, Perry D; van Kampen, Antoine H C

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

获得性 CYP19A1 扩增是 ERα 转移性乳腺癌中芳香化酶抑制剂耐药性的早期特异性机制

Magnani Luca, Frige Gianmaria, Gadaleta Raffaella Maria, Corleone Giacomo, Fabris Sonia, Kempe Mannus H, Verschure Pernette J, Barozzi Iros, Vircillo Valentina, Hong Sung-Pil, Perone Ylenia, Saini Massimo, Trumpp Andreas, Viale Giuseppe, Neri Antonino, Ali Simak, Colleoni Marco Angelo, Pruneri Giancarlo, Minucci Saverio

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model

亨廷顿病细胞模型中早期转录变化和聚集体形成的动态过程

van Hagen, Martijn; Piebes, Diewertje G E; de Leeuw, Wim C; Vuist, Ilona M; van Roon-Mom, Willeke M C; Moerland, Perry D; Verschure, Pernette J

The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise

单细胞的体积和转录本计数揭示了浓度稳态并捕捉了生物噪声。

Kempe, Hermannus; Schwabe, Anne; Crémazy, Frédéric; Verschure, Pernette J; Bruggeman, Frank J

Mechanistic stochastic model of histone modification pattern formation

组蛋白修饰模式形成的机制随机模型

Anink-Groenen, Lisette C M; Maarleveld, Timo R; Verschure, Pernette J; Bruggeman, Frank J

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

表观遗传编辑:通过靶向重写表观遗传标记来调节特定靶基因的表达

de Groote, Marloes L; Verschure, Pernette J; Rots, Marianne G

Heterochromatin protein 1 is recruited to various types of DNA damage

异染色质蛋白1被募集到各种类型的DNA损伤处。

Luijsterburg, Martijn S; Dinant, Christoffel; Lans, Hannes; Stap, Jan; Wiernasz, Elzbieta; Lagerwerf, Saskia; Warmerdam, Daniël O; Lindh, Michael; Brink, Maartje C; Dobrucki, Jurek W; Aten, Jacob A; Fousteri, Maria I; Jansen, Gert; Dantuma, Nico P; Vermeulen, Wim; Mullenders, Leon H F; Houtsmuller, Adriaan B; Verschure, Pernette J; van Driel, Roel

Pericentromeric heterochromatin domains are maintained without accumulation of HP1

着丝粒周围异染色质结构域得以维持,而HP1蛋白并未积累。

Mateos-Langerak, Julio; Brink, Maartje C; Luijsterburg, Martijn S; van der Kraan, Ineke; van Driel, Roel; Verschure, Pernette J