日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles

鉴定一种高度协同的PROTAC降解酶,该酶靶向GTP结合的KRAS(On)等位基因

Vetma, Vesna; Puoti, Ilaria; Karolak, Natalia K; Chakraborti, Sohini; Diers, Emelyne; Girardi, Enrico; Khan, Shakil; Kidd, Giorgia; Kropatsch, Katrin G; Mclennan, Ross; O'Connor, Suzanne; Samwer, Matthias; Trainor, Nicole; Whitworth, Claire; Wijaya, Andre J; Wong, Jeff Y F; Zollman, David; Farnaby, William; Popow, Johannes; Ciulli, Alessio; Ettmayer, Peter; McAulay, Kirsten

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

利用小分子调节 Cereblon 的开闭平衡会影响蛋白质降解

O'Connor, Suzanne; Rutter, Zoe J; Cowan, Angus D; Zeeb, Markus; Binder, Florian; Cao, Yuting; Chakraborti, Sohini; Djukic, Stefan; Geist, Leonhard; Hogg, Elizabeth; Kidd, Giorgia; Krumb, Matthias; Langer, Simon; Schmidt, Denis; Martin, Liam; McCrory, Elisha H; Padroni, Giacomo; Puoti, Ilaria; Simpson, Luke; Sturbaut, Manon; Crozier, Lisa; Vetma, Vesna; Zhang, Qingzhi; McAulay, Kirsten; Theis, Theodor; Ciulli, Alessio

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

选择性且口服生物可利用的 VHL 募集 PROTAC 在体内实现 SMARCA2 降解

Christiane Kofink #, Nicole Trainor #, Barbara Mair #, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E Fuchs, Thomas Gerstberger, Yun

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

三价 PROTAC 通过结合亲和力和协同作用增强蛋白质降解

Satomi Imaide #, Kristin M Riching #, Nikolai Makukhin #, Vesna Vetma, Claire Whitworth, Scott J Hughes, Nicole Trainor, Sarah D Mahan, Nancy Murphy, Angus D Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L Daniels, Alessio Ciulli

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism.

通路分析和模式识别的融合预测了IAP拮抗作用对最新一代TRAIL疗法的敏感性

Vetma Vesna, Guttà Cristiano, Peters Nathalie, Praetorius Christian, Hutt Meike, Seifert Oliver, Meier Friedegund, Kontermann Roland, Kulms Dagmar, Rehm Markus

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

磷蛋白模式可预测黑色素瘤对曲美替尼的反应性及最佳曲美替尼增敏策略

Jan Rožanc ,Theodore Sakellaropoulos ,Asier Antoranz ,Cristiano Guttà ,Biswajit Podder ,Vesna Vetma ,Nicole Rufo ,Patrizia Agostinis ,Vaia Pliaka ,Thomas Sauter ,Dagmar Kulms ,Markus Rehm ,Leonidas G Alexopoulos

Optimization of an ex vivo gene transfer to the hamstrings tendons muscle remnants: potential for genetic enhancement of bone healing

优化体外基因转移至腘绳肌腱残余组织:增强骨愈合的基因潜力

Rod, Eduard; Matić, Igor; Antunović, Maja; Vetma, Vesna; Pavičić, Ivan; Hudetz, Damir; Marijanović, Inga; Primorac, Dragan; Ivković, Alan

Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death

体外研究IAP拮抗剂Birinapant作为单药或与达卡巴嗪联合用药诱导黑色素瘤细胞死亡的功效

Vetma, Vesna; Rožanc, Jan; Charles, Emilie M; Hellwig, Christian T; Alexopoulos, Leonidas G; Rehm, Markus