日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

白血病暴露会改变骨髓微环境中 BCR::ABL1 阴性巨噬细胞的转录谱和功能。

Amy Dawson # ,Martha M Zarou # ,Bodhayan Prasad ,Joana Bittencourt-Silvestre ,Désirée Zerbst ,Ekaterini Himonas ,Ya-Ching Hsieh ,Isabel van Loon ,Giovanny Rodriguez Blanco ,Angela Ianniciello ,Zsombor Kerekes ,Vaidehi Krishnan ,Puneet Agarwal ,Hassan Almasoudi ,Laura McCluskey ,Lisa E M Hopcroft ,Mary T Scott ,Pablo Baquero ,Karen Dunn ,David Vetrie ,Mhairi Copland ,Ravi Bhatia ,Seth B Coffelt ,Ong Sin Tiong ,Helen Wheadon ,Sara Zanivan ,Kristina Kirschner ,G Vignir Helgason

Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease

激活 p53 可消除残留 CML 疾病中静止白血病干细胞的自我更新

Mary T Scott #, Wei Liu #, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Almasoudi, Thomas Stevens, Karen Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie

Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy

慢性粒细胞白血病中酪氨酸激酶抑制剂非依赖性基因表达特征为根除局灶性干细胞提供了新的靶点

Gómez-Castañeda, Eduardo; Hopcroft, Lisa E M; Rogers, Simon; Munje, Chinmay; Bittencourt-Silvestre, Joana; Copland, Mhairi; Vetrie, David; Holyoake, Tessa; Jørgensen, Heather G

The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia

剪接体:慢性粒细胞白血病的新治疗靶点

Benjamin Lebecque, Celine Bourgne, Chinmay Munje, Juliette Berger, Thomas Tassin, Pascale Cony-Makhoul, Agnès Guerci-Bresler, Hyacinthe Johnson-Ansah, Wei Liu, Sandrine Saugues, Andrei Tchirkov, David Vetrie, Mhairi Copland, Marc G Berger

ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy

ULK1抑制促进氧化应激诱导的分化,并使白血病干细胞对靶向治疗更加敏感

Angela Ianniciello ,Martha M Zarou ,Kevin M Rattigan ,Mary Scott ,Amy Dawson ,Karen Dunn ,Zuzana Brabcova ,Eric R Kalkman ,Colin Nixon ,Alison M Michie ,Mhairi Copland ,David Vetrie ,Martin Ambler ,Barbara Saxty ,G Vignir Helgason

A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival

KDM4A-PAF1 介导的表观基因组网络对于急性髓系白血病细胞的自我更新和存活至关重要

Matthew E Massett, Laura Monaghan, Shaun Patterson, Niamh Mannion, Roderick P Bunschoten, Alex Hoose, Sandra Marmiroli, Robert M J Liskamp, Heather G Jørgensen, David Vetrie, Alison M Michie, Xu Huang

Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML

慢性粒细胞白血病中的表观遗传重编程和新兴表观遗传疗法

Bugler, Jane; Kinstrie, Ross; Scott, Mary T; Vetrie, David

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

CML 细胞通过细胞因子介导的 MHC-II 表达下调主动逃避宿主的免疫监视

Anuradha Tarafdar, Lisa E M Hopcroft, Paolo Gallipoli, Francesca Pellicano, Jennifer Cassels, Alan Hair, Koorosh Korfi, Heather G Jørgensen, David Vetrie, Tessa L Holyoake, Alison M Michie

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

p53 和 c-MYC 的双重靶向选择性消除白血病干细胞

Sheela A Abraham, Lisa E M Hopcroft, Emma Carrick, Mark E Drotar, Karen Dunn, Andrew J K Williamson, Koorosh Korfi, Pablo Baquero, Laura E Park, Mary T Scott, Francesca Pellicano, Andrew Pierce, Mhairi Copland, Craig Nourse, Sean M Grimmond, David Vetrie, Anthony D Whetton, Tessa L Holyoake

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

表观遗传重编程使 CML 干细胞对 EZH2 和酪氨酸激酶联合抑制敏感

Mary T Scott, Koorosh Korfi, Peter Saffrey, Lisa E M Hopcroft, Ross Kinstrie, Francesca Pellicano, Carla Guenther, Paolo Gallipoli, Michelle Cruz, Karen Dunn, Heather G Jorgensen, Jennifer E Cassels, Ashley Hamilton, Andrew Crossan, Amy Sinclair, Tessa L Holyoake, David Vetrie