Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
基于一系列蛋白酶体抑制剂的支架跃迁策略,我们获得了一种用于治疗内脏利什曼病的临床前候选药物。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c00047
Thomas, Michael; Brand, Stephen; De Rycker, Manu; Zuccotto, Fabio; Lukac, Iva; Dodd, Peter G; Ko, Eun-Jung; Manthri, Sujatha; McGonagle, Kate; Osuna-Cabello, Maria; Riley, Jennifer; Pont, Caterina; Simeons, Frederick; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Viayna, Elisabet; Fiandor, Jose M; Martin, Julio; Wyatt, Paul G; Miles, Timothy J; Read, Kevin D; Marco, Maria; Gilbert, Ian H