Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation
羟基脲通过磷酸二酯酶 4A 激活抑制内皮路德/基底细胞粘附分子 (Lu/BCAM),从而降低镰状网织红细胞与静息内皮的粘附
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M113.506121
Vicky Chaar, Sandrine Laurance, Claudine Lapoumeroulie, Sylvie Cochet, Maria De Grandis, Yves Colin, Jacques Elion, Caroline Le Van Kim, Wassim El Nemer