日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.

自噬通过 SQSTM1/p62 介导的选择性自噬来调节细胞衰老,从而介导 CDKN1A/p21 和 CDKN2A/p16 的降解,进而导致粘液瘤样二尖瓣退化

Tang Qiyu, Tang Keyi, Markby Greg R, Parys Maciej, Phadwal Kanchan, MacRae Vicky E, Corcoran Brendan M

Mitochondrial Dysfunction as a Potential Mechanism Mediating Cardiac Comorbidities in Parkinson's Disease

线粒体功能障碍可能是帕金森病心脏合并症的潜在机制

Salis Torres, Agustina; Lee, Ji-Eun; Caporali, Andrea; Semple, Robert K; Horrocks, Mathew H; MacRae, Vicky E

TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease

TGF-β 诱导的 PI3K/AKT/mTOR 通路通过调节自然发生的粘液瘤性二尖瓣疾病犬模型中的细胞衰老来控制肌成纤维细胞分化和瓣膜间质细胞的分泌表型

Qiyu Tang, Greg R Markby, Andrew J MacNair, Keyi Tang, Michal Tkacz, Maciej Parys, Kanchan Phadwal, Vicky E MacRae, Brendan M Corcoran

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease

TGF-β磷酸化抗体芯片鉴定出SMAD2、PI3K/AKT/SMAD和RAC信号通路改变与黏液瘤样二尖瓣疾病的发病机制相关。

McNair, Andrew J; Markby, Greg R; Tang, Qiyu; MacRae, Vicky E; Corcoran, Brendan M

Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery

间歇性甲状旁腺激素给药引起的骨骼合成代谢反应期间,PHOSPHO1 和碱性磷酸酶的表达增加

Houston, Dean A; Stephen, Louise A; Jayash, Soher N; Myers, Katherine; Little, Kirsty; Hopkinson, Mark; Pitsillides, Andrew A; MacRae, Vicky E; Millan, Jose Luis; Staines, Katherine A; Farquharson, Colin

p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification

p53 调节血管平滑肌细胞钙化中的线粒体动力学

Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K Semple, Ian G Ganley, Vicky E MacRae

Bone mineralisation and glucose metabolism

骨矿化和葡萄糖代谢

Roberts, Fiona L; MacRae, Vicky E

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

心肌细胞通过干扰非心肌细胞中的嘧啶生物合成来调节心脏修复。

Li, Shen; Yokota, Tomohiro; Wang, Ping; Ten Hoeve, Johanna; Ma, Feiyang; Le, Thuc M; Abt, Evan R; Zhou, Yonggang; Wu, Rimao; Nanthavongdouangsy, Maxine; Rodriguez, Abraham; Wang, Yijie; Lin, Yen-Ju; Muranaka, Hayato; Sharpley, Mark; Braddock, Demetrios T; MacRae, Vicky E; Banerjee, Utpal; Chiou, Pei-Yu; Seldin, Marcus; Huang, Dian; Teitell, Michael; Gertsman, Ilya; Jung, Michael; Bensinger, Steven J; Damoiseaux, Robert; Faull, Kym; Pellegrini, Matteo; Lusis, Aldons J; Graeber, Thomas G; Radu, Caius G; Deb, Arjun

Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

二甲双胍通过 p62 自噬受体选择性降解 Runx2 来防止血管钙化

Kanchan Phadwal, Eve Koo, Ross A Jones, Rachael O Forsythe, Keyi Tang, Qiyu Tang, Brendan M Corcoran, Andrea Caporali, Vicky E MacRae

PALMD regulates aortic valve calcification via altered glycolysis and NF-κB-mediated inflammation

PALMD通过改变糖酵解和NF-κB介导的炎症反应来调节主动脉瓣钙化。

Wang, Siying; Yu, Hongjiao; Gao, Jun; Chen, Jiaxin; He, Pengcheng; Zhong, Hui; Tan, Xiao; Staines, Katherine A; Macrae, Vicky E; Fu, Xiaodong; Jiang, Lei; Zhu, Dongxing