Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment
INPP4B 缺失会导致 BRCA1、ATM 和 ATR 缺失，从而造成 DNA 修复缺陷，可通过 PARP 抑制剂治疗进行针对性治疗
期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.3307
Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner
