Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3)

抑制 AML 细胞中的 Cot1/Tlp2 致癌基因可降低 ERK5 活化并上调 p27Kip1，同时增强水飞蓟宾和 1,25-二羟基维生素 D(3) 诱导的分化和细胞周期停滞