日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

TREM2 缺陷导致小鼠脑淀粉样血管病模型出现区域特异性脑损伤

Mercado, Constanza; Amaro, Armando; Martinez-Pinto, Jonathan; Vidal, Ruben; Jury-Garfe, Nur; Lasagna-Reeves, Cristian A

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

TREM2 缺陷导致小鼠脑淀粉样血管病模型出现区域特异性脑损伤

Wang, Yiqin; Wen, Qiong; Jin, Luhua; Chen, Wei; Mercado, Constanza; Amaro, Armando; Martinez-Pinto, Jonathan; Vidal, Ruben; Jury-Garfe, Nur; Lasagna-Reeves, Cristian A

Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds

模拟疾病相关tau蛋白折叠结构和功能的环状β-拱形肽

Angera, Isaac J; Xu, Xueyong; Rajewski, Benjamin H; Hallinan, Grace I; Zhang, Xiaoqi; Ghetti, Bernardino; Vidal, Ruben; Jiang, Wen; Del Valle, Juan R

Tau depletion diminishes vascular amyloid-related deficits in a mouse model of cerebral amyloid angiopathy.

在脑淀粉样血管病小鼠模型中,Tau蛋白的减少可减轻血管淀粉样蛋白相关的缺陷

Jury-Garfe Nur, Chimal-Juárez Enrique, Patel Henika, Martinez-Pinto Jonathan, Vanderbosch Kathryn, Mardones Muriel D, Perkins Abigail, Prisco Gonzalo Viana Di, Marambio Yamil, Vidal Ruben, Atwood Brady K, Lasagna-Reeves Cristian A

Distinct tau filament folds in human MAPT mutants P301L and P301T

人类MAPT突变体P301L和P301T中tau蛋白丝的独特折叠

Schweighauser, Manuel; Shi, Yang; Murzin, Alexey G; Garringer, Holly J; Vidal, Ruben; Murrell, Jill R; Erro, M Elena; Seelaar, Harro; Ferrer, Isidro; van Swieten, John C; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

更正:在杂合子患者状态下,可通过一系列先进化合物克服侵袭性阿尔茨海默病致病早老素突变体的γ-分泌酶调节剂耐药性。

Trambauer, Johannes; Sarmiento, Rosa Maria Rodriguez; Garringer, Holly J; Salbaum, Katja; Pedro, Liliana D; Crusius, Dennis; Vidal, Ruben; Ghetti, Bernardino; Paquet, Dominik; Baumann, Karlheinz; Lindemann, Lothar; Steiner, Harald

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

双配体荧光显微镜能够对不同的β-淀粉样蛋白沉积物进行时间顺序和空间组织学鉴定。

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie; Hammarström, Per; Graff, Caroline; Ingelsson, Martin; Vidal, Ruben; Ghetti, Bernardino; Sehlin, Dag; Syvänen, Stina; Nilsson, K Peter R

Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation.

在两种 tau 蛋白病小鼠模型中,丝氨酸 214 的磷酸化与 tau 蛋白的播种活性呈年龄依赖性相关,并且是 tau 蛋白跨突触传播所必需的。

Martinez Pablo, Jury-Garfe Nur, Patel Henika, You Yanwen, Perkins Abigail, You Yingjian, Lee-Gosselin Audrey, Vidal Ruben, Lasagna-Reeves Cristian A

Cryo-EM structures of amyloid-β and tau filaments in Down syndrome

唐氏综合征中淀粉样β蛋白和tau蛋白丝的冷冻电镜结构

Fernandez, Anllely; Hoq, Md Rejaul; Hallinan, Grace I; Li, Daoyi; Bharath, Sakshibeedu R; Vago, Frank S; Zhang, Xiaoqi; Ozcan, Kadir A; Newell, Kathy L; Garringer, Holly J; Jiang, Wen; Ghetti, Bernardino; Vidal, Ruben

Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease

噻吩基配体用于阿尔茨海默病中不同Aβ病理的特异性鉴定

Klingstedt, Therése; Lantz, Linda; Shirani, Hamid; Ge, Junyue; Hanrieder, Jörg; Vidal, Ruben; Ghetti, Bernardino; Nilsson, K Peter R