日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overcoming claudin family homology: discovery of ARC101, a highly potent CLDN6-specific T-cell engager with a novel CD3 binder for ovarian adenocarcinoma.

克服 claudin 家族同源性:发现 ARC101,一种高效的 CLDN6 特异性 T 细胞衔接器,具有新型 CD3 结合剂,可用于治疗卵巢腺癌。

Yang Danlin, Kamran Neha, Shivange Gururaj, Kumari Kavita, Yavvari Prabhu Srinivas, Chaugule Viduth K, Mahajan Vishal, Larkin Bridget, Brodeur Scott R, Erhardt Joe, Singh Sanjaya

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Nedd4-2 依赖的星形胶质细胞 Kir4.1 和 Connexin43 调节控制神经网络活动

Bekir Altas, Hong-Jun Rhee #, Anes Ju #, Hugo Cruces Solís #, Samir Karaca #, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L Wieser, Viduth K Chaugule, Irina Majoul, Mohamed A Hassan, Rashi Goel, Sonja M Wojcik, Noriko Koganezawa, K

Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination

FANCI-FANCD2泛素化相互依赖的结构和生化基础

Lemonidis, Kimon; Rennie, Martin L; Arkinson, Connor; Chaugule, Viduth K; Clarke, Mairi; Streetley, James; Walden, Helen

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

Cryo-EM 揭示了通过隐秘结合位点抑制 USP1 的机制

Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Helen Walden

Allosteric mechanism for site-specific ubiquitination of FANCD2

FANCD2 位点特异性泛素化的变构机制

Viduth K Chaugule, Connor Arkinson, Martin L Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

FANCI 和 FANCD2 泛素化的差异功能稳定 DNA 上的 ID2 复合物

Martin L Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo, Helen Walden

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

UbcH7~Ub 和磷酸化 Ubl 结构域的协同募集触发帕金蛋白的激活

Condos, Tara Ec; Dunkerley, Karen M; Freeman, E Aisha; Barber, Kathryn R; Aguirre, Jacob D; Chaugule, Viduth K; Xiao, Yiming; Konermann, Lars; Walden, Helen; Shaw, Gary S

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation

RNF12 X 连锁智力障碍突变破坏 E3 连接酶活性和神经分化

Francisco Bustos, Anna Segarra-Fas, Viduth K Chaugule, Lennart Brandenburg, Emma Branigan, Rachel Toth, Thomas Macartney, Axel Knebel, Ronald T Hay, Helen Walden, Greg M Findlay

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

DHX15 调节 CMTR1 依赖的基因表达和细胞增殖

Francisco Inesta-Vaquera, Viduth K Chaugule, Alison Galloway, Laurel Chandler, Alejandro Rojas-Fernandez, Simone Weidlich, Mark Peggie, Victoria H Cowling

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

单泛素化 FANCD2 去泛素化的特异性由 USP1 的 N 端驱动

Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden