Vignir相关文献与解析，生知库 | 链接生命科学的每一步

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

抑制线粒体叶酸代谢可通过 mTORC1 介导的嘌呤感知驱动细胞分化。

Martha M Zarou ，Kevin M Rattigan ，Daniele Sarnello ，Engy Shokry ，Amy Dawson ，Angela Ianniciello ，Karen Dunn ，Mhairi Copland ，David Sumpton ，Alexei Vazquez ，G Vignir Helgason

细胞生物学

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

白血病暴露会改变骨髓微环境中 BCR::ABL1 阴性巨噬细胞的转录谱和功能。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-45471-0

Amy Dawson # ，Martha M Zarou # ，Bodhayan Prasad ，Joana Bittencourt-Silvestre ，Désirée Zerbst ，Ekaterini Himonas ，Ya-Ching Hsieh ，Isabel van Loon ，Giovanny Rodriguez Blanco ，Angela Ianniciello ，Zsombor Kerekes ，Vaidehi Krishnan ，Puneet Agarwal ，Hassan Almasoudi ，Laura McCluskey ，Lisa E M Hopcroft ，Mary T Scott ，Pablo Baquero ，Karen Dunn ，David Vetrie ，Mhairi Copland ，Ravi Bhatia ，Seth B Coffelt ，Ong Sin Tiong ，Helen Wheadon ，Sara Zanivan ，Kristina Kirschner ，G Vignir Helgason

Metabolism in stem cell-driven leukemia: parallels between hematopoiesis and immunity

干细胞驱动型白血病中的代谢：造血与免疫的相似之处

期刊:Blood

影响因子:23.1

doi:10.1182/blood.2022018258

Rattigan, Kevin M; Zarou, Martha M; Helgason, G Vignir

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

甘露糖代谢抑制通过诱导铁死亡使急性髓系白血病细胞对治疗更加敏感

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-37652-0

Keith Woodley ，Laura S Dillingh ，George Giotopoulos ，Pedro Madrigal ，Kevin M Rattigan ，Céline Philippe ，Vilma Dembitz ，Aoife M S Magee ，Ryan Asby ，Louie N van de Lagemaat ，Christopher Mapperley ，Sophie C James ，Jochen H M Prehn ，Konstantinos Tzelepis ，Kevin Rouault-Pierre ，George S Vassiliou ，Kamil R Kranc ，G Vignir Helgason ，Brian J P Huntly ，Paolo Gallipoli

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

丙酮酸补充代谢是持续性白血病干细胞的一个可靶向的脆弱点。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-40222-z

Kevin M Rattigan # ，Zuzana Brabcova # ，Daniele Sarnello ，Martha M Zarou ，Kiron Roy ，Ryan Kwan ，Lucie de Beauchamp ，Amy Dawson ，Angela Ianniciello ，Ahmed Khalaf ，Eric R Kalkman ，Mary T Scott ，Karen Dunn ，David Sumpton ，Alison M Michie ，Mhairi Copland ，Saverio Tardito ，Eyal Gottlieb ，G Vignir Helgason

Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches

揭示衰老造血干细胞群的异质性：来自单细胞方法的启示

期刊:Hemasphere

影响因子:14.6

doi:10.1097/HS9.0000000000000895

Yang, Fei; Nourse, Craig; Helgason, G Vignir; Kirschner, Kristina

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

精氨酸依赖性是慢性粒细胞白血病干细胞中一个具有治疗潜力的弱点。

期刊:EMBO Reports

影响因子:6.5

doi:10.15252/embr.202256279

Kevin M Rattigan ，Martha M Zarou ，Zuzana Brabcova ，Bodhayan Prasad ，Désirée Zerbst ，Daniele Sarnello ，Eric R Kalkman ，Angela Ianniciello ，Mary T Scott ，Karen Dunn ，Engy Shokry ，David Sumpton ，Mhairi Copland ，Saverio Tardito ，Johan Vande Voorde ，Francis Mussai ，Paul Cheng ，G Vignir Helgason

Young Adult Male Patients With Childhood-onset IBD Have Increased Risks of Compromised Cortical and Trabecular Bone Microstructures

儿童期发病的炎症性肠病（IBD）青年男性患者皮质骨和松质骨微结构受损的风险增加

期刊:Inflammatory Bowel Diseases

影响因子:4.3

doi:10.1093/ibd/izac181

Sigurdsson, Gudmundur Vignir; Schmidt, Susanne; Mellström, Dan; Ohlsson, Claes; Saalman, Robert; Lorentzon, Mattias

Changes in health-related lifestyle choices of university students before and during the COVID-19 pandemic: Associations between food choices, physical activity and health

新冠疫情前后大学生健康相关生活方式选择的变化：食物选择、身体活动与健康之间的关联

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0286345

Jakobsdottir, Greta; Stefansdottir, Runa Sif; Gestsdottir, Sunna; Stefansson, Vignir; Johannsson, Erlingur; Rognvaldsdottir, Vaka; Gisladottir, Thordis Lilja

Maternal postpartum infection risk following induction of labor: A Danish national cohort study

引产后产妇感染风险：一项丹麦全国队列研究

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

抑制线粒体叶酸代谢可通过 mTORC1 介导的嘌呤感知驱动细胞分化。

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

白血病暴露会改变骨髓微环境中 BCR::ABL1 阴性巨噬细胞的转录谱和功能。

Metabolism in stem cell-driven leukemia: parallels between hematopoiesis and immunity

干细胞驱动型白血病中的代谢：造血与免疫的相似之处

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

甘露糖代谢抑制通过诱导铁死亡使急性髓系白血病细胞对治疗更加敏感

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

丙酮酸补充代谢是持续性白血病干细胞的一个可靶向的脆弱点。

Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches

揭示衰老造血干细胞群的异质性：来自单细胞方法的启示

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

精氨酸依赖性是慢性粒细胞白血病干细胞中一个具有治疗潜力的弱点。

Young Adult Male Patients With Childhood-onset IBD Have Increased Risks of Compromised Cortical and Trabecular Bone Microstructures

儿童期发病的炎症性肠病（IBD）青年男性患者皮质骨和松质骨微结构受损的风险增加

Changes in health-related lifestyle choices of university students before and during the COVID-19 pandemic: Associations between food choices, physical activity and health

新冠疫情前后大学生健康相关生活方式选择的变化：食物选择、身体活动与健康之间的关联