日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境增强癌症检查点免疫疗法的疗效。

Elizabeth L Hardaker # ,Emilio Sanseviero # ,Ankur Karmokar # ,Devon Taylor # ,Marta Milo ,Chrysis Michaloglou ,Adina Hughes ,Mimi Mai ,Matthew King ,Anisha Solanki ,Lukasz Magiera ,Ricardo Miragaia ,Gozde Kar ,Nathan Standifer ,Michael Surace ,Shaan Gill ,Alison Peter ,Sara Talbot ,Sehmus Tohumeken ,Henderson Fryer ,Ali Mostafa ,Kathy Mulgrew ,Carolyn Lam ,Scott Hoffmann ,Daniel Sutton ,Larissa Carnevalli ,Fernando J Calero-Nieto ,Gemma N Jones ,Andrew J Pierce ,Zena Wilson ,David Campbell ,Lynet Nyoni ,Carla P Martins ,Tamara Baker ,Gilberto Serrano de Almeida ,Zainab Ramlaoui ,Abdel Bidar ,Benjamin Phillips ,Joseph Boland ,Sonia Iyer ,J Carl Barrett ,Arsene-Bienvenu Loembé ,Serge Y Fuchs ,Umamaheswar Duvvuri ,Pei-Jen Lou ,Melonie A Nance ,Carlos Alberto Gomez Roca ,Elaine Cadogan ,Susan E Critichlow ,Steven Fawell ,Mark Cobbold ,Emma Dean ,Viia Valge-Archer ,Alan Lau ,Dmitry I Gabrilovich ,Simon T Barry

Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma

小型基因网络可界定免疫细胞状态并表征黑色素瘤的免疫治疗反应

Egan, Donagh; Kreileder, Martina; Nabhan, Myriam; Iglesias-Martinez, Luis F; Dovedi, Simon J; Valge-Archer, Viia; Grover, Amit; Wilkinson, Robert W; Slidel, Timothy; Bendtsen, Claus; Barrett, Ian P; Brennan, Donal J; Kolch, Walter; Zhernovkov, Vadim

Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments

年龄引起的抗肿瘤免疫变化会改变肿瘤免疫浸润,并影响对免疫肿瘤治疗的反应。

Sitnikova, Suzanne I; Walker, Jennifer A; Prickett, Laura B; Morrow, Michelle; Valge-Archer, Viia E; Robinson, Matthew J; Wilkinson, Robert W; Dovedi, Simon J

ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

ATM 调节肌成纤维细胞癌相关成纤维细胞的分化,并可以作为克服免疫疗法耐药性的靶点

Massimiliano Mellone, Klaudia Piotrowska, Giulia Venturi, Lija James, Aleksandra Bzura, Maria A Lopez, Sonya James, Chuan Wang, Matthew J Ellis, Christopher J Hanley, Josephine F Buckingham, Kerry L Cox, Gareth Hughes, Viia Valge-Archer, Emma V King, Stephen A Beers, Vincent Jaquet, George D D Jones

PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors

PARP抑制剂是BRCA缺陷型肿瘤中抗肿瘤免疫反应的调节剂。

Staniszewska, Anna D; Armenia, Joshua; King, Matthew; Michaloglou, Chrysiis; Reddy, Avinash; Singh, Maneesh; San Martin, Maryann; Prickett, Laura; Wilson, Zena; Proia, Theresa; Russell, Deanna; Thomas, Morgan; Delpuech, Oona; O'Connor, Mark J; Leo, Elisabetta; Angell, Helen; Valge-Archer, Viia

Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation

靶向 DNA 损伤反应成分可在 ATM 缺陷型癌细胞中诱导增强的 STING 依赖性 I 型干扰素反应,并驱动树突状细胞活化

Marta Lopez-Pelaez, Lucy Young, Mercedes Vazquez-Chantada, Nadine Nelson, Steve Durant, Robert W Wilkinson, Edmund Poon, Miguel Gaspar, Viia Valge-Archer, Paul Smith, Simon J Dovedi

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

MEK抑制剂可将CD8+ T淋巴细胞重编程为具有强大抗肿瘤作用的记忆干细胞。

Vivek Verma ,Nazli Jafarzadeh ,Shannon Boi ,Subhadip Kundu ,Zhinuo Jiang ,Yiping Fan ,Jose Lopez ,Rahul Nandre ,Peng Zeng ,Fatmah Alolaqi ,Shamim Ahmad ,Pankaj Gaur ,Simon T Barry ,Viia E Valge-Archer ,Paul D Smith ,Jacques Banchereau ,Mikayel Mkrtichyan ,Benjamin Youngblood ,Paulo C Rodriguez ,Seema Gupta ,Samir N Khleif

Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control

AZD7648 抑制 DNA-PK 可增强肿瘤细胞对放射疗法的敏感性,并诱导 I 型 IFN 依赖性持久肿瘤控制

Kyoko Nakamura, Ankur Karmokar, Paul M Farrington, Neil H James, Antonio Ramos-Montoya, Susan J Bickerton, Gareth D Hughes, Timothy M Illidge, Elaine B Cadogan, Barry R Davies, Simon J Dovedi #, Viia Valge-Archer #

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

解析 BET 溴结构域蛋白 BRD2 和 BRD4 在人类 NK 细胞功能中的作用

Adam P Cribbs, Panagis Filippakopoulos, Martin Philpott, Graham Wells, Henry Penn, Henrik Oerum, Viia Valge-Archer, Marc Feldmann, Udo Oppermann

Gluten-degrading bacteria: availability and applications

麸质降解菌:可用性和应用

Kõiv, Viia; Tenson, Tanel