日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.

肝脏活性素通过血管系统逆转衰老和阿尔茨海默病相关的记忆丧失。

Bieri Gregor, Pratt Karishma J B, Fuseya Yasuhiro, Aghayev Turan, Sucharov Juliana, Horowitz Alana M, Philp Amber R, Fonseca-Valencia Karla, Chu Rebecca, Phan Mason, Remesal Laura, Wang Shih-Hsiu J, Yang Andrew C, Casaletto Kaitlin B, Villeda Saul A

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

针对老年大脑中的免疫细胞的研究表明,工程细胞因子 IL-10 可以增强神经发生并改善认知能力。

Navarro Negredo Paloma, You Justin, Hauptschein Max, Schroer Adam B, Richard Daniel J, Abhiraman Gita C, Tsai Andy P, Sun Eric D, Notarangelo Giulia, Ramirez-Matias Julliana, Zhou Olivia Y, Buckley Matthew T, Malacon Karen E, Xu Lucy, Sucharov Juliana, Ramirez Lopez Eduardo, Picton Lora, Wyss-Coray Tony, Saxton Robert A, Fernandes Ricardo A, Villeda Saul A, Garcia K Christopher, Brunet Anne

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

系统性地鉴定驱动细胞和组织再生的单个转录因子扰动

Sengstack, Janine; Zheng, Jiashun; Aghayev, Turan; Bieri, Gregor; Mobaraki, Michael; Lin, Jue; Deng, Changhui; Villeda, Saul A; Li, Hao

Diabetes Induces Accumulation of Carbonylated Proteins in the Rat Retinal Pigment Epithelium Independently of Oxidative Stress.

糖尿病可诱导大鼠视网膜色素上皮细胞中羰基化蛋白的积累,且该过程与氧化应激无关。

Morales-Ramírez Elena, Villeda-González Juan David, Sánchez-Chávez Gustavo, Salceda Rocío

Halt aging? - functional HSCs lead the way

延缓衰老?——功能性造血干细胞引领方向

Chu, Rebecca T; Schroer, Adam B; Villeda, Saul A

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.

靶向老年小鼠大脑中的铁相关蛋白Ftl1可改善与年龄相关的认知障碍。

Remesal Laura, Sucharov-Costa Juliana, Wu Yuting, Pratt Karishma J B, Bieri Gregor, Philp Amber, Phan Mason, Aghayev Turan, White Charles W 3rd, Wheatley Elizabeth G, Zou Bende, Desousa Brandon R, Couthouis Julien, Jian Isha H, Xie Xinmin S, Lu Yi, Maynard Jason C, Burlingame Alma L, Villeda Saul A

Spatial coding dysfunction and network instability in the aging medial entorhinal cortex

衰老内侧内嗅皮层的空间编码功能障碍和网络不稳定性

Herber, Charlotte S; Pratt, Karishma J B; Shea, Jeremy M; Villeda, Saul A; Giocomo, Lisa M

Biocompatible low-voltage electrothermal actuators with biological operational temperature range

具有生物相容性、生物工作温度范围的低压电热致动器

Slavíková, Adéla; Baker, Benjamin C; Villeda-Hernandez, Marcos; Coekin, Annabel; Kwasniewska, Julia; Good, Tim; Aleemardani, Mina; Snethen, Heidi; Armstrong, James P K; Faul, Charl F J

Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

海马体中小胶质细胞的衰老会经历一系列中间状态,这些状态会导致激活和认知衰退。

Jeremy M Shea ,Saul A Villeda

Potential Effects of Nicotinamide on Serum HDL-Cholesterol Levels and Hepatic Oxidative Stress, ABCA1 Gene and Protein Expression in Rats Fed a High-Fat/Fructose Diet.

烟酰胺对喂食高脂/果糖饮食的大鼠血清高密度脂蛋白胆固醇水平和肝脏氧化应激、ABCA1基因和蛋白质表达的潜在影响。

Serafín-Fabián Jesús I, Ramírez-Cruz Armando, Villeda-González J D, Gómez-Zamudio Jaime, Hernández-Díazcouder Adrián, Ortega-Camarillo Clara, Flores-Alfaro Eugenia, Cruz Miguel, Vazquez-Moreno Miguel