日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accelerated Combinatorial Drug Design for Human Immunodeficiency Virus Resistance through Seeded Multisite λ-Dynamics

通过种子多位点λ动力学加速组合药物设计以对抗人类免疫缺陷病毒耐药性

Bowling, Paige E; Vilseck, Jonah Z; Brooks, Charles L 3rd

EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery

EXOSC3 G191 变异体触发 RNA 加工机制的系统性重新校准

Wijeratne, H R Sagara; Runnebohm, Avery M; Barron, Monica P; Hampton, Ariana J; Li, Rudong; Peck Justice, Sarah A; Lenceski, Sophia H; Rooney, James D; Smith-Kinnaman, Whitney R; Chang, Gina S; Doud, Emma H; Kim, Jungsu; Pelletier, Stephane; Liu, Yunlong; Vilseck, Jonah Z; Mosley, Amber L

In silico λ-dynamics predicts protein binding specificities to modified RNAs

计算机模拟λ动力学预测蛋白质与修饰RNA的结合特异性

Angelo, Murphy; Zhang, Wen; Vilseck, Jonah Z; Aoki, Scott T

The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling.

人类胰腺导管腺癌 (PDAC) 中过氧化物酶-1 的缺失,与 Ref-1 氧化还原信号的抑制相结合,会显著降低细胞存活率和肿瘤生长。

Kiran Sonia, Wireman Randall S, Peil Jacqueline, Mitchell Dana K, Potchanant Elizabeth Sierra, Rai Ratan, Vilseck Jonah Z, Cao Sha, Haiaty Sanya, Georgiadis Millie M, Fishel Melissa L, Kelley Mark R

Multisite λ-Dynamics for Protein-DNA Binding Affinity Prediction

用于预测蛋白质-DNA结合亲和力的多位点λ动力学

Al Masri, Carmen; Vilseck, Jonah Z; Yu, Jin; Hayes, Ryan L

Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1

化学诱导的多功能脱嘌呤/脱嘧啶核酸内切酶1的部分展开

Rai, Ratan; Dawodu, Olabode I; Meng, Jingwei; Johnson, Steven M; Vilseck, Jonah Z; Kelley, Mark R; Ziarek, Joshua J; Georgiadis, Millie M

Accurate in silico predictions of modified RNA interactions to a prototypical RNA-binding protein with λ-dynamics

利用计算机模拟准确预测修饰RNA与具有λ动力学的典型RNA结合蛋白的相互作用

Angelo, Murphy; Bhargava, Yash; Kierzek, Elzbieta; Kierzek, Ryszard; Hayes, Ryan L; Zhang, Wen; Vilseck, Jonah Z; Aoki, Scott Takeo

Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations

多分子λ动力学:利用蛋白质和配体同时扰动探测耐药性

Liesen, Michael P; Hayes, Ryan L; Brooks Iii, Charles L; Vilseck, Jonah Z

Quantifying the Structural and Energetic Consequences of EXOSC3 S1 Domain Variants from a Comparative Assessment of λ-Dynamics with Two Charge-Changing Perturbation Strategies

通过两种电荷改变扰动策略对λ动力学的比较评估,量化EXOSC3 S1结构域变体的结构和能量后果

Barron, Monica P; Wijeratne, H R Sagara; Runnebohm, Avery M; Caric, Katelyn M; Mosley, Amber L; Vilseck, Jonah Z

EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA.

与 PCH1b 相关的 EXOSC3 S1 结构域变体改变了 RNA 外泌体帽亚基的丰度和热稳定性,从而破坏了 rRNA 加工和富含 AU 的 mRNA 的靶向

Runnebohm Avery M, Wijeratne H R Sagara, Barron Monica P, Smith-Kinnaman Whitney R, Rooney James D, Peck Justice Sarah A, Cureton Lauryn A, Holland Annalise, Ghalei Homa, Pelletier Stephane, Doud Emma H, Vilseck Jonah Z, Mosley Amber L