日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthetic lethality of decitabine plus ATR inhibition for TP53-mutated AML

地西他滨联合ATR抑制剂对TP53突变型急性髓系白血病具有合成致死性

Baeten, Jeremy T; Agashe, Sumedha; Tabet, Imene; Wooldridge, Jack T; Carter, Amber; Butler, Jamie N; Miller, Christopher A; Helton, Nicole; Quinet, Annabel; Johansson, Kimberly B; Yang, Yichan; Uy, Geoffrey L; Vindigni, Alessandro; Link, Daniel C

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

BRCA1-A 复合物限制 ATM 缺陷细胞中依赖于复制叉逆转的 DNA 修复。

Datta Arindam, Jackson Jessica, Morozov Yaroslav I, Qiu Jinghan, Vindigni Alessandro, Greenberg Roger A

MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage.

MRN-CtIP、EXO1 和 DNA2-WRN/BLM 双向作用于 PARPi 处理的细胞中的 DNA 缺口,而不会造成链断裂

Seppa Isabelle M, Ceppi Ilaria, Tennakoon Mithila, Reginato Giordano, Jackson Jessica, Rouault Celia D, Agashe Sumedha, Sviderskiy Vladislav O, Limbu Mangsi, Lantelme Erica, Meroni Alice, Braunshier Stefan, Borrello Damiano, Verma Priyanka, Cejka Petr, Vindigni Alessandro

The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.

SMC5/6 复合物可防止 APOBEC3A 介导的复制压力引起的基因毒性

Fingerman Dylan F, O'Leary David R, Hansen Ava R, Tran Thi, Harris Brooke R, DeWeerd Rachel A, Hayer Katharina E, Fan Jiayi, Chen Emily, Tennakoon Mithila, Meroni Alice, Szeto Julia H, Devenport Jessica, LaVigne Danielle, Weitzman Matthew D, Shalem Ophir, Bednarski Jeffrey, Vindigni Alessandro, Zhao Xiaolan, Green Abby M

Leveraging the replication stress response to optimize cancer therapy

利用复制应激反应优化癌症治疗

Cybulla, Emily; Vindigni, Alessandro

RAD51 bypasses the CMG helicase to promote replication fork reversal

RAD51绕过CMG解旋酶,促进复制叉逆转

Liu, Wenpeng; Saito, Yuichiro; Jackson, Jessica; Bhowmick, Rahul; Kanemaki, Masato T; Vindigni, Alessandro; Cortez, David

Studying Single-Stranded DNA Gaps at Replication Intermediates by Electron Microscopy

利用电子显微镜研究复制中间体的单链DNA缺口

Jackson, Jessica; Vindigni, Alessandro

ISG15 fast-tracks DNA replication

ISG15加速DNA复制

Meroni, Alice; Vindigni, Alessandro

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

断裂诱导复制促进致命连接分子的形成,这些连接分子会被Srs2溶解。

Elango, Rajula; Sheng, Ziwei; Jackson, Jessica; DeCata, Jenna; Ibrahim, Younis; Pham, Nhung T; Liang, Diana H; Sakofsky, Cynthia J; Vindigni, Alessandro; Lobachev, Kirill S; Ira, Grzegorz; Malkova, Anna

Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics

结合电子显微镜和单分子DNA纤维技术研究DNA复制动力学

Vindigni, Alessandro; Lopes, Massimo