日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

核内sirtuin SIRT6保护心脏免受与衰老相关的心肌细胞衰老和心脏肥大的影响。

Pillai, Vinodkumar B; Samant, Sadhana; Hund, Samantha; Gupta, Madhu; Gupta, Mahesh P

Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets

骨骼肌特异性过度表达核 sirtuin SIRT6 通过调节多个靶点来阻断癌症相关的恶病质

Sadhana A Samant, Vinodkumar B Pillai, Mahesh P Gupta

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

核和线粒体的 Sirtuins(Sirt6 和 Sirt3)相互调节彼此的活动,保护心脏免于患上肥胖介导的糖尿病性心肌病

Abhinav Kanwal, Vinodkumar B Pillai, Sadhana Samant, Madhu Gupta, Mahesh P Gupta

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy

组蛋白去乙酰化酶 SIRT6 阻断肌生长抑制素的表达和肌肉萎缩的发展

Sadhana A Samant, Abhinav Kanwal, Vinodkumar B Pillai, Riyue Bao, Mahesh P Gupta

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage

SIRT3通过阻止线粒体DNA损伤来抑制肌成纤维细胞分化和肺纤维化。

Bindu, Samik; Pillai, Vinodkumar B; Kanwal, Abhinav; Samant, Sadhana; Mutlu, Gökhan M; Verdin, Eric; Dulin, Nickolai; Gupta, Mahesh P

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

厚朴酚是Sirtuin-3 (SIRT3) 的激活剂,能够保护线粒体并防止小鼠心脏受到阿霉素诱导的心肌病损害。

Pillai, Vinodkumar B; Kanwal, Abhinav; Fang, Yong Hu; Sharp, Willard W; Samant, Sadhana; Arbiser, Jack; Gupta, Mahesh P

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

Sirt3 保护线粒体 DNA 损伤并阻止小鼠阿霉素诱发的心肌病的发展

Vinodkumar B Pillai, Samik Bindu, Will Sharp, Yong Hu Fang, Gene Kim, Madhu Gupta, Sadhana Samant, Mahesh P Gupta

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

和厚朴酚通过激活线粒体 Sirt3 阻断和逆转小鼠心脏肥大

Vinodkumar B Pillai, Sadhana Samant, Nagalingam R Sundaresan, Hariharasundaram Raghuraman, Gene Kim, Michael Y Bonner, Jack L Arbiser, Douglas I Walker, Dean P Jones, David Gius, Mahesh P Gupta

Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity

组蛋白去乙酰化酶 3 (HDAC3) 依赖的心脏肌球蛋白重链异构体的可逆赖氨酸乙酰化调节其酶和运动活性

Sadhana A Samant, Vinodkumar B Pillai, Nagalingam R Sundaresan, Sanjeev G Shroff, Mahesh P Gupta

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

SIRT3 通过去乙酰化和激活糖原合酶激酶 3β 来阻断小鼠衰老相关的组织纤维化

Nagalingam R Sundaresan, Samik Bindu, Vinodkumar B Pillai, Sadhana Samant, Yong Pan, Jing-Yi Huang, Madhu Gupta, Raghu S Nagalingam, Donald Wolfgeher, Eric Verdin, Mahesh P Gupta