日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of AMPK potentiates inflammation by activating the infammasome in a preclinical mouse model of TBI

在创伤性脑损伤的临床前小鼠模型中,AMPK 的缺失通过激活炎症小体加剧炎症反应。

Ahmed, Mohammad Ejaz; Suhail, Hamid; Nematullah, Mohammad; Viollet, Benoit; Giri, Shailendra; Ahmad, Abdullah Shafique

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

苯乙双胍(而非二甲双胍)通过细胞自主性AMPK激活延缓T细胞急性淋巴细胞白血病/淋巴瘤的发展

Vara-Ciruelos, Diana; Dandapani, Madhumita; Russell, Fiona M; Grzes, Katarzyna M; Atrih, Abdelmadjid; Foretz, Marc; Viollet, Benoit; Lamont, Douglas J; Cantrell, Doreen A; Hardie, D Grahame

Acute Cold Exposure Cell-Autonomously Reduces mTORC1 Signaling and Protein Synthesis Independent of AMPK

急性寒冷暴露通过细胞自主的方式降低 mTORC1 信号传导和蛋白质合成,且该过程不依赖于 AMPK。

Sung, Benjamin Y; Ford, Eliza J; Foster, Daniel J; Fullmer, Kyler J; Cromwell, Cosette; Viollet, Benoit; Thomson, David M

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response.

直接药理学激活 AMPK 可抑制粘膜 SARS-CoV-2 感染,其机制是通过降低脂质代谢、恢复自噬通量和 I 型 IFN 反应

Cottignies-Calamarte Andrea, Marteau Flora, He Feifan, Belouzard Sandrine, Dubuisson Jean, Tudor Daniela, Viollet Benoit, Bomsel Morgane

Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway

热量限制会将石胆酸阻断到溶酶体AMPK通路中。

Viollet, Benoit

Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis

促进代谢适应:溶酶体AMPK启动谷氨酰胺分解

Viollet, Benoit; Guigas, Bruno

Myeloid Cell-Specific Deletion of AMPKα1 Worsens Ocular Bacterial Infection by Skewing Macrophage Phenotypes

髓系细胞特异性敲除AMPKα1通过改变巨噬细胞表型加剧眼部细菌感染

Singh, Sukhvinder; Singh, Pawan Kumar; Ahmad, Zeeshan; Das, Susmita; Foretz, Marc; Viollet, Benoit; Giri, Shailendra; Kumar, Ashok

Metformin: update on mechanisms of action and repurposing potential

二甲双胍:作用机制和再利用潜力的最新进展

Foretz, Marc; Guigas, Bruno; Viollet, Benoit

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

心脏AMP激活蛋白激酶在非病理状态下的作用:来自心肌细胞特异性诱导型AMP激活蛋白激酶α1α2敲除小鼠的证据

Tokarska-Schlattner, Malgorzata; Kay, Laurence; Perret, Pascale; Isola, Raffaella; Attia, Stéphane; Lamarche, Frédéric; Tellier, Cindy; Cottet-Rousselle, Cécile; Uneisi, Amjad; Hininger-Favier, Isabelle; Foretz, Marc; Dubouchaud, Hervé; Ghezzi, Catherine; Zuppinger, Christian; Viollet, Benoit; Schlattner, Uwe

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

二甲双胍通过激活葡萄糖磷酸化下游的糖酵解途径,降低肝细胞中葡萄糖-6-磷酸的水平。

Moonira, Tabassum; Chachra, Shruti S; Ford, Brian E; Marin, Silvia; Alshawi, Ahmed; Adam-Primus, Natasha S; Arden, Catherine; Al-Oanzi, Ziad H; Foretz, Marc; Viollet, Benoit; Cascante, Marta; Agius, Loranne