日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.

特定 P2X 受体拮抗剂的神经保护作用源于其抑制神经胶质细胞中 NLRP3 炎症小体组装的能力

Murphy Niamh, Cowley Thelma R, Richardson Jill C, Virley David, Upton Neil, Walter Daryl, Lynch Marina A

5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease

5-HT6受体拮抗剂作为阿尔茨海默病的新型认知增强剂

Upton, Neil; Chuang, Tsu Tshen; Hunter, Ann J; Virley, David J

Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

反复给予去甲肾上腺素能神经毒素N-(2-氯乙基)-N-乙基-2-溴苄胺(DSP-4)可调节携带淀粉样前体蛋白和早老素-1突变转基因的小鼠的神经炎症和淀粉样斑块负荷。

Pugh, Perdita L; Vidgeon-Hart, Martin P; Ashmeade, Tracey; Culbert, Ainsley A; Seymour, Zoe; Perren, Marion J; Joyce, Flora; Bate, Simon T; Babin, Anna; Virley, David J; Richardson, Jill C; Upton, Neil; Sunter, David

Developing therapeutics for the treatment of multiple sclerosis

开发治疗多发性硬化症的疗法

Virley, David J