日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H(1) receptor

利用基于片段的药物发现方法将3D支架转化为高效配体：以组胺H(1)受体为例

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md01081k
Dekker, Tom; van Linden, Oscar P J; Lim, Herman D; Dekker, Mabel E; Vischer, Henry F; Leurs, Rob; van der Meer, Tiffany; Buzink, Maurice C M L; Hamilton, David J; Zarzycka, Barbara; Janssen, Elwin; Wijtmans, Maikel; de Esch, Iwan J P
3D/类器官
信号转导
发表日期：2026
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A Radiolabeled Photoswitchable G Protein-Coupled Receptor Antagonist Enlightens Ligand Binding Kinetics Associated with Photoswitching

放射性标记的光开关G蛋白偶联受体拮抗剂揭示了与光开关相关的配体结合动力学

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c07349
Binkhorst, Lars C P; Josimovic, Ivana; De Boer, Bas; Simon, Icaro A; Van Der Aa, Frank; Zarzycka, Barbara A; De Esch, Iwan J P; Vischer, Henry F; Windhorst, Albert D; Wijtmans, Maikel; Leurs, Rob
信号转导
发表日期：2025
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Recent Developments in the Optical Control of Adrenergic Signaling

肾上腺素能信号光学控制的最新进展

期刊:Medicinal Research Reviews
影响因子:11.6
doi:10.1002/med.22110
Shi, Shuang; Cao, Yangzhi; Wijtmans, Maikel; Vischer, Henry F; Leurs, Rob
信号转导
免疫/内分泌
发表日期：2025
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Photo-clenbuterol: Optical Control of β(2)-Adrenergic Receptor Signaling by Photoswitchable Ligand Efficacy.

光克仑特罗：通过光开关配体效力对β(2)-肾上腺素能受体信号传导进行光学控制

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00792
Cao Yangzhi, Shi Shuang, Does Simone A H, Buzink Christian M L, Gao Meichun, de Esch Iwan J P, Vischer Henry F, Wijtmans Maikel, Leurs Rob
信号转导
发表日期：2025
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Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3

首个非典型趋化因子受体3的光开关小分子激动剂的设计、合成和药理学表征

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.4c11583
Bérenger, Sophie; Adamska, Justyna M; Deflorian, Francesca; de Graaf, Chris; Palmer, Christie B; Szpakowska, Martyna; Chevigné, Andy; de Esch, Iwan J P; Zarzycka, Barbara; Vischer, Henry F; Wijtmans, Maikel; Leurs, Rob
信号转导
免疫/内分泌
发表日期：2025
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Design and synthesis of photoswitchable desloratadine ligands for histamine H(1) receptor photopharmacology

组胺H(1)受体光药理学用光开关地氯雷他定配体的设计与合成

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00589b
Binkhorst, Lars C P; Josimovic, Ivana; de Vetten, Daan; Nijman, Tyrone J; Hauwert, Niels J; Ahmad, Sufyan; van Linden, Oscar P J; de Esch, Iwan J P; Vischer, Henry F; Wijtmans, Maikel; Leurs, Rob
信号转导
发表日期：2025
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Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840

小分子反向激动剂VUF16840对非典型趋化因子受体3组成活性的抑制

期刊:Molecular Pharmacology
影响因子:3
doi:10.1016/j.molpha.2025.100085
Bosma, Reggie; Nesheva, Desislava; Rijnsburger, Merel; Riemens, Rick; Adamska, Justyna M; Meyrath, Max; Mobach, Simon; Buzink, C Maurice; van der Pol, Suzanne; de Esch, Iwan J P; Szpakowska, Martyna; Wijtmans, Maikel; Chevigne, Andy; Vischer, Henry F; Leurs, Rob
信号转导
免疫/内分泌
发表日期：2025
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Structural basis of ligand recognition and design of antihistamines targeting histamine H(4) receptor.

组胺H(4)受体配体识别的结构基础及抗组胺药设计

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-024-46840-5
Xia Ruixue, Shi Shuang, Xu Zhenmei, Vischer Henry F, Windhorst Albert D, Qian Yu, Duan Yaning, Liang Jiale, Chen Kai, Zhang Anqi, Guo Changyou, Leurs Rob, He Yuanzheng
信号转导
发表日期：2024
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Histamine H(3) Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity

组胺H(3)受体亚型：从选择性剪接到功能复杂性的启示

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom14070761
Gao, Meichun; Ooms, Jasper F; Leurs, Rob; Vischer, Henry F
信号转导
发表日期：2024
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A Photoswitchable Agonist for the Histamine H(3) Receptor, a Prototypic Family A G-Protein-Coupled Receptor

组胺H(3)受体的光开关激动剂，一种典型的A家族G蛋白偶联受体

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201813110
Hauwert, Niels J; Mocking, Tamara A M; Da Costa Pereira, Daniel; Lion, Ken; Huppelschoten, Yara; Vischer, Henry F; De Esch, Iwan J P; Wijtmans, Maikel; Leurs, Rob
信号转导
发表日期：2019
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