日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues

分子胶对 14-3-3σ/C-RAF“自身”抑制复合物的调节

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c12622
Konstantinidou, Markella; Vickery, Holly R; Pennings, Marloes A M; Virta, Johanna M; Luo, Shu Yue; Visser, Emira J; Bannier, Sean D; Srikanth, Mrudula; Cismoski, Sabine Z; Young, Lucy C; van den Oetelaar, Maxime C M; McCormick, Frank; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R
发表日期：2026
文献求助 收藏

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

调节性ChREBP/14-3-3复合物的分子粘合剂保护β细胞免受糖脂毒性损伤

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-57241-7
Katz, Liora S; Visser, Emira J; Plitzko, Kathrin F; Pennings, Marloes A M; Cossar, Peter J; Tse, Isabelle L; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K
ChREBP
细胞生物学
毒理研究
EBP
发表日期：2025
文献求助 收藏

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

针对 14-3-3/ERα 复合物的分子胶的支架跃迁

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-61176-4
Konstantinidou Markella, Zingiridis Marios, Pennings Marloes A M, Fragkiadakis Michael, Virta Johanna M, Revalde Jezrael L, Visser Emira J, Ottmann Christian, Brunsveld Luc, Neochoritis Constantinos G, Arkin Michelle R
其它
发表日期：2025
文献求助 收藏

Modulation of the 14-3-3σ/C-RAF "auto"inhibited complex by molecular glues

分子胶对14-3-3σ/C-RAF“自身”抑制复合物的调节

期刊:
影响因子:
doi:10.1101/2025.07.30.667769
Konstantinidou, Markella; Vickery, Holly R; Pennings, Marloes A M; Virta, Johanna M; Visser, Emira J; Bannier, Sean D; Srikanth, Mrudula; Cismoski, Sabine Z; Young, Lucy C; van den Oetelaar, Maxime C M; McCormick, Frank; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R
发表日期：2025
文献求助 收藏

From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking

通过片段连接实现14-3-3蛋白-蛋白相互作用的从束缚型到独立型稳定剂

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202308004
Visser, Emira J; Jaishankar, Priyadarshini; Sijbesma, Eline; Pennings, Marloes A M; Vandenboorn, Edmee M F; Guillory, Xavier; Neitz, R Jeffrey; Morrow, John; Dutta, Shubhankar; Renslo, Adam R; Brunsveld, Luc; Arkin, Michelle R; Ottmann, Christian
发表日期：2023
文献求助 收藏

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments

基于非选择性片段的14-3-3σ/ERα蛋白-蛋白相互作用共价小分子稳定剂的结构优化

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.3c05161
Konstantinidou, Markella; Visser, Emira J; Vandenboorn, Edmee; Chen, Sheng; Jaishankar, Priyadarshini; Overmans, Maurits; Dutta, Shubhankar; Neitz, R Jeffrey; Renslo, Adam R; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R
发表日期：2023
文献求助 收藏

A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers

系统性地发现蛋白质-蛋白质相互作用稳定剂

期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.2c01449
Kenanova, Dyana N; Visser, Emira J; Virta, Johanna M; Sijbesma, Eline; Centorrino, Federica; Vickery, Holly R; Zhong, Mengqi; Neitz, R Jeffrey; Brunsveld, Luc; Ottmann, Christian; Arkin, Michelle R
发表日期：2023
文献求助 收藏

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

14-3-3枢纽蛋白的功能定位及其在14-3-3分子胶设计中的应用

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d2sc04662h
Somsen, Bente A; Craenmehr, Fenna W B; Liu, Wei-Hong W; Koops, Auke A; Pennings, Marloes A M; Visser, Emira J; Ottmann, Christian; Cossar, Peter J; Brunsveld, Luc
发表日期：2022
文献求助 收藏