日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Senolytic treatment alleviates doxorubicin-induced chemobrain

衰老细胞清除疗法可缓解阿霉素诱发的化疗脑

Vivekananda Budamagunta, Ashok Kumar, Asha Rani, Sahana Manohar Sindhu, Yang Yang, Daohong Zhou, Thomas C Foster

Effect of peripheral cellular senescence on brain aging and cognitive decline

外周细胞衰老对大脑衰老和认知衰退的影响

Vivekananda Budamagunta ,Ashok Kumar ,Asha Rani ,Linda Bean ,Sahana Manohar-Sindhu ,Yang Yang ,Daohong Zhou ,Thomas C Foster

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

将 BCL-XL 和 MCL-1 与 DT2216 和 AZD8055 共同靶向可协同抑制小细胞肺癌生长,且不会在小鼠中引起靶向毒性

Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J Kaye, Daohong Zhou

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216

使用 BCL-XL 特异性降解剂 DT2216 克服胰腺癌的吉西他滨耐药性

Dinesh Thummuri #, Sajid Khan #, Patrick W Underwood #, Peiyi Zhang, Janet Wiegand, Xuan Zhang, Vivekananda Budamagunta, Amin Sobh, Abderrahmane Tagmount, Alexander Loguinov, Andrea N Riner, Ashwin S Akki, Elizabeth Williamson, Robert Hromas, Christopher D Vulpe, Guangrong Zheng, Jose G Trevino, Dao

Senescence-associated hyper-activation to inflammatory stimuli in vitro

体外衰老相关的炎症刺激过度激活

Vivekananda Budamagunta, Sahana Manohar-Sindhu, Yang Yang, Yonghan He, Dmitry O Traktuev, Thomas C Foster, Daohong Zhou

DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

DT2216——一种Bcl-xL特异性降解剂,对Bcl-xL依赖性T细胞淋巴瘤具有很高的活性。

Yonghan He ,Raphael Koch ,Vivekananda Budamagunta ,Peiyi Zhang ,Xuan Zhang ,Sajid Khan ,Dinesh Thummuri ,Yuma T Ortiz ,Xin Zhang ,Dongwen Lv ,Janet S Wiegand ,Wen Li ,Adam C Palmer ,Guangrong Zheng ,David M Weinstock ,Daohong Zhou

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

利用靶向蛋白水解的嵌合体技术降低纳维托克(navitoclax)的血小板毒性并提高其衰老细胞清除活性

Yonghan He # ,Xuan Zhang # ,Jianhui Chang # ,Ha-Neui Kim # ,Peiyi Zhang ,Yingying Wang ,Sajid Khan ,Xingui Liu ,Xin Zhang ,Dongwen Lv ,Lin Song ,Wen Li ,Dinesh Thummuri ,Yaxia Yuan ,Janet S Wiegand ,Yuma T Ortiz ,Vivekananda Budamagunta ,Jennifer H Elisseeff ,Judith Campisi ,Maria Almeida ,Guangrong Zheng ,Daohong Zhou

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

发现 IAP 募集的 BCL-XL PROTAC 可作为多种癌细胞系的强效降解剂

Xuan Zhang, Yonghan He, Peiyi Zhang, Vivekananda Budamagunta, Dongwen Lv, Dinesh Thummuri, Yang Yang, Jing Pei, Yaxia Yuan, Daohong Zhou, Guangrong Zheng