日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

Sestrin 调节剂 NV-5138 通过直接激活 mTORC1 产生快速抗抑郁作用

Taro Kato, Santosh Pothula, Rong-Jian Liu, Catharine H Duman, Rosemarie Terwilliger, George P Vlasuk, Eddine Saiah, Seung Hahm, Ronald S Duman

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

Rheb 的小分子抑制剂选择性地靶向 mTORC1 信号通路

Sarah J Mahoney ,Sridhar Narayan ,Lisa Molz ,Lauren A Berstler ,Seong A Kang ,George P Vlasuk ,Eddine Saiah

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

SIRT1激活剂SRT1720可延长喂食标准饲料的小鼠的寿命并改善其健康状况。

Mitchell, Sarah J; Martin-Montalvo, Alejandro; Mercken, Evi M; Palacios, Hector H; Ward, Theresa M; Abulwerdi, Gelareh; Minor, Robin K; Vlasuk, George P; Ellis, James L; Sinclair, David A; Dawson, John; Allison, David B; Zhang, Yongqing; Becker, Kevin G; Bernier, Michel; de Cabo, Rafael

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Sirtuin 1 激活剂 SRT2104 可保护亨廷顿病小鼠

Jiang, Mali; Zheng, Jennifer; Peng, Qi; Hou, Zhipeng; Zhang, Jiangyang; Mori, Susumu; Ellis, James L; Vlasuk, George P; Fries, Harvey; Suri, Vipin; Duan, Wenzhen

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

羧酰胺类SIRT1抑制剂通过一种不依赖于乙酰化的机制阻断DBC1结合。

Hubbard, Basil P; Loh, Christine; Gomes, Ana P; Li, Jun; Lu, Quinn; Doyle, Taylor Lg; Disch, Jeremy S; Armour, Sean M; Ellis, James L; Vlasuk, George P; Sinclair, David A

SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity

SIRT1 激活剂通过促进 p65 去乙酰化和抑制 NF-κB 活性来抑制炎症反应

Hongying Yang, Wei Zhang, Heng Pan, Heidi G Feldser, Elden Lainez, Christine Miller, Stewart Leung, Zhong Zhong, Huizhen Zhao, Sharon Sweitzer, Thomas Considine, Thomas Riera, Vipin Suri, Brian White, James L Ellis, George P Vlasuk, Christine Loh

A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers

一项针对老年志愿者的新型SIRT1激活剂SRT2104的随机、安慰剂对照、双盲I期试验

Libri, Vincenzo; Brown, Andrew P; Gambarota, Giulio; Haddad, Jonathan; Shields, Gregory S; Dawes, Helen; Pinato, David J; Hoffman, Ethan; Elliot, Peter J; Vlasuk, George P; Jacobson, Eric; Wilkins, Martin R; Matthews, Paul M

SRT1720 improves survival and healthspan of obese mice

SRT1720 可提高肥胖小鼠的存活率和健康寿命

Minor, Robin K; Baur, Joseph A; Gomes, Ana P; Ward, Theresa M; Csiszar, Anna; Mercken, Evi M; Abdelmohsen, Kotb; Shin, Yu-Kyong; Canto, Carles; Scheibye-Knudsen, Morten; Krawczyk, Melissa; Irusta, Pablo M; Martín-Montalvo, Alejandro; Hubbard, Basil P; Zhang, Yongqing; Lehrmann, Elin; White, Alexa A; Price, Nathan L; Swindell, William R; Pearson, Kevin J; Becker, Kevin G; Bohr, Vilhelm A; Gorospe, Myriam; Egan, Josephine M; Talan, Mark I; Auwerx, Johan; Westphal, Christoph H; Ellis, James L; Ungvari, Zoltan; Vlasuk, George P; Elliott, Peter J; Sinclair, David A; de Cabo, Rafael

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator

小分子激活SIRT1:酶与激活剂直接相互作用的动力学和生物物理学证据

Dai, Han; Kustigian, Lauren; Carney, David; Case, April; Considine, Thomas; Hubbard, Basil P; Perni, Robert B; Riera, Thomas V; Szczepankiewicz, Bruce; Vlasuk, George P; Stein, Ross L

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

LXR配体可降低灵长类动物的低密度脂蛋白胆固醇水平,对仓鼠的脂质水平无影响,并可减轻小鼠的动脉粥样硬化。

Quinet, Elaine M; Basso, Michael D; Halpern, Anita R; Yates, David W; Steffan, Robert J; Clerin, Valerie; Resmini, Christine; Keith, James C; Berrodin, Thomas J; Feingold, Irene; Zhong, Wenyan; Hartman, Helen B; Evans, Mark J; Gardell, Stephen J; DiBlasio-Smith, Elizabeth; Mounts, William M; LaVallie, Edward R; Wrobel, Jay; Nambi, Ponnal; Vlasuk, George P