日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes.

利用构象响应染料的蛋白质自适应差示扫描荧光法

Wu Taiasean, Yu Joshua C, Suresh Arundhati, Gale-Day Zachary J, Alteen Matthew G, Woo Amanda S, Millbern Zoe, Johnson Oleta T, Carroll Emma C, Partch Carrie L, Fourches Denis, Vinueza Nelson R, Vocadlo David J, Gestwicki Jason E

Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease

基于酶活性的全基因组溶酶体葡糖脑苷脂酶修饰因子筛选揭示帕金森病潜在风险因素

Udayar, Vinod; Gilormini, Pierre-André; Bryois, Julien; Gehrlein, Alexandra; Chen, Xi; Sonea, Stephanie; Zhu, Sha; Deen, Matthew C; Anastasi, Nadia; Murphy, Alan E; Skene, Nathan; Tan, Manuela M X; Tunold, Jon-Anders; Roudnicky, Filip; van de Berg, Wilma D J; Pihlstrøm, Lasse; Vocadlo, David J; Jagasia, Ravi

A proto-aldehyde fluorescence quenched substrate for quantitative imaging of both protein and enzyme activity within cells

一种用于细胞内蛋白质和酶活性定量成像的原醛荧光猝灭底物

Zhu, Sha; Deen, Matthew C; Cecioni, Samy; Wong, Kim Lam; Perley-Roberston, Evan; Wu, Weifeng Benny; Vocadlo, David J

A gram-scale synthesis of β-L-carbafucose for engineering antibody glycans

用于抗体聚糖工程的β-L-碳酸岩藻糖的克级合成

Thota, V Narasimharao; Fers-Lidou, Anthony; Nodwell, Matthew; McDonagh, Anthony W; Gilormini, Pierre-André; Wang, Yang; Leung, Carolyn; Vocadlo, David J; Britton, Robert

Expansion of the diversity of dispersin scaffolds

分散蛋白支架多样性的扩展

Males, Alexandra; Moroz, Olga V; Blagova, Elena; Munch, Astrid; Hansen, Gustav H; Johansen, Annette H; Østergaard, Lars H; Segura, Dorotea R; Eddenden, Alexander; Due, Anne V; Gudmand, Martin; Salomon, Jesper; Sørensen, Sebastian R; Franco Cairo, João Paulo L; Nitz, Mark; Pache, Roland A; Vejborg, Rebecca M; Bhosale, Sandeep; Vocadlo, David J; Davies, Gideon J; Wilson, Keith S

A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases

一种自毁型Kdn-糖苷底物可用于高通量筛选Kdn酶抑制剂。

Nejatie, Ali; Proceviat, Cameron; Gros, Christina; Steves, Elizabeth; Moore, Margo M; Vocadlo, David J; Bennet, Andrew J

A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells

一种用于定量活细胞中底物水平和GCase活性的双功能底物

Tiet, Ben; Zhu, Sha; Chen, Xi; Anastasi, Nadia; See, Nicholas W; Deen, Matthew C; Harde, Eva; Vocadlo, David J

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.

常见的帕金森病风险 GBA1 变异会破坏 LIMP2 相互作用,损害葡萄糖脑苷脂酶功能,并导致溶酶体和线粒体功能障碍

Davis Oliver B, Kung Jennifer E, Davis Sonnet S, Ghosh Rajarshi, Andrews Shan V, Gould Neal S, Kluss Jillian H, Thomsen Elliot, Agam Maayan, Coan John P, Maloney Michael T, Nguyen Ann H, Nguyen Hoang N, Propson Nicholas E, Lozano Edwin I, Yuan Tianao, Xa Kaitlin, Sperberg R Andres Parra, Jain Shourya, Lawrence Roger, Ullman Julie C, Balasundar Srijana, Benton H Paul, Petkovic Maja, Qerqez Ahlam N, Wang Xiang, Zhu Sha, Di Paolo Gilbert, Kariolis Mihalis S, Mahon Cathal S, Arguello Annie, Vocadlo David J, Cookson Mark R, Suh Jung H, Rougé Lionel, Henry Anastasia G

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

开发可通过形成瞬态共价中间体稳定糖苷水解酶的可调控机制型碳糖配体

Bhosale, Sandeep; Kandalkar, Sachin; Gilormini, Pierre-André; Akintola, Oluwafemi; Rowland, Rhianna; Adabala, Pal John Pal; King, Dustin; Deen, Matthew C; Chen, Xi; Davies, Gideon J; Vocadlo, David J; Bennet, Andrew J

High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease

利用高通量筛选方法寻找戈谢病和帕金森病中错误折叠的葡糖脑苷脂酶的小分子稳定剂

Williams, Darian; Glasstetter, Logan M; Jong, Tiffany T; Chen, Tiffany; Kapoor, Abhijeet; Zhu, Sha; Zhu, Yanping; Calvo, Raul; Gehrlein, Alexandra; Wong, Kimberly; Hogan, Andrew N; Vocadlo, David J; Jagasia, Ravi; Marugan, Juan J; Sidransky, Ellen; Henderson, Mark J; Chen, Yu