日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Cryo-EM reveals an unprecedented binding site for Na(V)1.7 inhibitors enabling rational design of potent hybrid inhibitors

冷冻电镜揭示了Na(V)1.7抑制剂前所未有的结合位点，从而能够合理设计高效的混合抑制剂。

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.84151
Kschonsak, Marc; Jao, Christine C; Arthur, Christopher P; Rohou, Alexis L; Bergeron, Philippe; Ortwine, Daniel F; McKerrall, Steven J; Hackos, David H; Deng, Lunbin; Chen, Jun; Li, Tianbo; Dragovich, Peter S; Volgraf, Matthew; Wright, Matthew R; Payandeh, Jian; Ciferri, Claudio; Tellis, John C
发表日期：2023
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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.

GluN2A NMDA 受体增强可改善 Dravet 综合征和阿尔茨海默病模型中的脑振荡、同步性和认知功能

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2019.12.030
Hanson Jesse E, Ma Keran, Elstrott Justin, Weber Martin, Saillet Sandrine, Khan Abdullah S, Simms Jeffrey, Liu Benjamin, Kim Thomas A, Yu Gui-Qiu, Chen Yelin, Wang Tzu-Ming, Jiang Zhiyu, Liederer Bianca M, Deshmukh Gauri, Solanoy Hilda, Chan Connie, Sellers Benjamin D, Volgraf Matthew, Schwarz Jacob B, Hackos David H, Weimer Robby M, Sheng Morgan, Gill T Michael, Scearce-Levie Kimberly, Palop Jorge J
神经科学
发表日期：2020
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TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

哌啶甲酰胺对TRPA1的调节作用表明其结合位点和门控机制在进化上是保守的。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1913929116
Chernov-Rogan, Tania; Gianti, Eleonora; Liu, Chang; Villemure, Elisia; Cridland, Andrew P; Hu, Xiaoyu; Ballini, Elisa; Lange, Wienke; Deisemann, Heike; Li, Tianbo; Ward, Stuart I; Hackos, David H; Magnuson, Steven; Safina, Brian; Klein, Michael L; Volgraf, Matthew; Carnevale, Vincenzo; Chen, Jun
RPA1
TRPA1
发表日期：2019
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Allosteric control of an ionotropic glutamate receptor with an optical switch

利用光开关对离子型谷氨酸受体进行变构控制

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/nchembio756
Volgraf, Matthew; Gorostiza, Pau; Numano, Rika; Kramer, Richard H; Isacoff, Ehud Y; Trauner, Dirk
信号转导
发表日期：2006
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