日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.

RNA剪接抑制会触发CHMP7进入细胞核,影响TDP-43的功能,从而导致ALS细胞表型的出现

Al-Azzam Norah, To Jenny H, Gautam Vaishali, Street Lena A, Nguyen Chloe B, Naritomi Jack T, Lam Dylan C, Madrigal Assael A, Lee Benjamin, Jin Wenhao, Avina Anthony, Mizrahi Orel, Mueller Jasmine R, Ford Willard, Schiavon Cara R, Rebollo Elena, Vu Anthony Q, Blue Steven M, Madakamutil Yashwin L, Manor Uri, Rothstein Jeffrey D, Coyne Alyssa N, Jovanovic Marko, Yeo Gene W

Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization

亨廷顿病小鼠和人类脑组织均表现出G3BP1颗粒增多和TDP43错位

Sanchez, Isabella I; Nguyen, Thai B; England, Whitney E; Lim, Ryan G; Vu, Anthony Q; Miramontes, Ricardo; Byrne, Lauren M; Markmiller, Sebastian; Lau, Alice L; Orellana, Iliana; Curtis, Maurice A; Faull, Richard Lewis Maxwell; Yeo, Gene W; Fowler, Christie D; Reidling, Jack C; Wild, Edward J; Spitale, Robert C; Thompson, Leslie M

Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins

整合全基因组分析揭示了hnRNP蛋白对可变剪接的协同调控作用

Huelga, Stephanie C; Vu, Anthony Q; Arnold, Justin D; Liang, Tiffany Y; Liu, Patrick P; Yan, Bernice Y; Donohue, John Paul; Shiue, Lily; Hoon, Shawn; Brenner, Sydney; Ares, Manuel Jr; Yeo, Gene W