日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug

利用NQO1激活前药选择性靶向NRF2高表达的胰腺导管腺癌

Antonucci, Laura; Watari, Kosuke; Feng, Yechen; Qi, Jingjing; Zhu, Mandy; Wang, Tingya; Ng, Isabella; Vucic, Emily A; Riahi, Irene; Huang, Li; Hosseini, Mojgan; Mose, Evangeline; French, Randall; Weitz, Jonathan; Bar-Sagi, Dafna; Dawson, David W; Sun, Beicheng; Tiriac, Herve; Xu, Jinyi; Xu, Shengtao; Lowy, Andrew M; Karin, Michael

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

自我扩增的 NRF2-EZH2 表观遗传环将 KRAS 启动的祖细胞转化为侵袭性胰腺癌

Antonucci Laura, Li Na, Duran Angeles, Cobo Isidoro, Nicoletti Chiara, Watari Kosuke, Nandi Shuvro Prokash, Zhu Feng, Zhao Yongmei, Riahi Irene, Tsuda Motoyuki, Shah Vidhi M, Morgan Terry, Waugh Trent, Caputo Luca, Liu Yuan, Rundberg Nilsson Alexandra, Xian Hongxu, Todoric Jelena, Gu Li, Sanchez-Lopez Elsa, Eibl Guido, Vucic Emily A, Krawczyk Michal, Xu Qianlan, Lowy Andrew M, Hatzivassiliou Georgia, Roose-Girma Merone, Skowronska-Krawczyk Dorota, Scott David A, Bar-Sagi Dafna, Tamayo Pablo, Wu Ying, Sears Rosalie C, Glass Christopher K, Alexandrov Ludmil B, Puri Pier Lorenzo, Dawson David W, Hu Yinling, Diaz-Meco Maria T, Moscat Jorge, Karin Michael

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging

通过高通量成像技术揭示实体瘤微环境中细胞间相互作用的空间分布

Cohn, David E; Forder, Aisling; Marshall, Erin A; Vucic, Emily A; Stewart, Greg L; Noureddine, Kouther; Lockwood, William W; MacAulay, Calum E; Guillaud, Martial; Lam, Wan L

Reactivation of Multiple Fetal miRNAs in Lung Adenocarcinoma

肺腺癌中多种胎儿 miRNA 的重新激活

Cohn, David E; Barros-Filho, Mateus C; Minatel, Brenda C; Pewarchuk, Michelle E; Marshall, Erin A; Vucic, Emily A; Sage, Adam P; Telkar, Nikita; Stewart, Greg L; Jurisica, Igor; Reis, Patricia P; Robinson, Wendy P; Lam, Wan L

Decreased microbiome diversity in the HIV small airway epithelium

HIV感染者小气道上皮细胞微生物群多样性降低

Xu, Stella; Tsai, Amy; Sze, Marc A; Vucic, Emily A; Shaipanich, Tawimas; Harris, Marianne; Guillemi, Silvia; Yang, Julia; Sinha, Sunita; Nislow, Corey; Montaner, Julio; Lam, Wan; Lam, Stephen; Sin, Don D; Paul Man, S F; Leung, Janice M

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

小气道上皮细胞端粒长度缩短表明感染人类免疫缺陷病毒(HIV)的人肺部衰老加速。

Xu, Stella; Vucic, Emily A; Shaipanich, Tawimas; Lam, Stephen; Lam, Wan; Montaner, Julio S; Sin, Don D; Paul Man, S F; Leung, Janice M

Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes

肺腺癌中差异表达的microRNA逆转了预后基因拷贝数异常的影响

Tokar, Tomas; Pastrello, Chiara; Ramnarine, Varune R; Zhu, Chang-Qi; Craddock, Kenneth J; Pikor, Larrisa A; Vucic, Emily A; Vary, Simon; Shepherd, Frances A; Tsao, Ming-Sound; Lam, Wan L; Jurisica, Igor

Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis

T辅助细胞17和调节性T细胞在肺癌进展和转移中的新兴作用

Marshall, Erin A; Ng, Kevin W; Kung, Sonia H Y; Conway, Emma M; Martinez, Victor D; Halvorsen, Elizabeth C; Rowbotham, David A; Vucic, Emily A; Plumb, Adam W; Becker-Santos, Daiana D; Enfield, Katey S S; Kennett, Jennifer Y; Bennewith, Kevin L; Lockwood, William W; Lam, Stephen; English, John C; Abraham, Ninan; Lam, Wan L

The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus

支气管上皮细胞细菌微生物组和人类免疫缺陷病毒感染患者的宿主反应

Sze, Marc A; Xu, Stella; Leung, Janice M; Vucic, Emily A; Shaipanich, Tawimas; Moghadam, Aida; Harris, Marianne; Guillemi, Silvia; Sinha, Sunita; Nislow, Corey; Murphy, Darra; Hague, Cameron; Leipsic, Jonathon; Lam, Stephen; Lam, Wan; Montaner, Julio S; Sin, Don D; Man, S F Paul

DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways

DNA甲基化在全球范围内受到破坏,并与慢性阻塞性肺疾病小气道中的表达变化相关。

Vucic, Emily A; Chari, Raj; Thu, Kelsie L; Wilson, Ian M; Cotton, Allison M; Kennett, Jennifer Y; Zhang, May; Lonergan, Kim M; Steiling, Katrina; Brown, Carolyn J; McWilliams, Annette; Ohtani, Keishi; Lenburg, Marc E; Sin, Don D; Spira, Avrum; Macaulay, Calum E; Lam, Stephen; Lam, Wan L