Vulpe Christopher相关文献与解析，生知库

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.

全基因组 CRISPR/Cas9 筛选鉴定出与儿童急性髓系白血病 (AML) 预后相关的 AraC-柔红霉素-依托泊苷反应调节剂

doi:10.1182/bloodadvances.2024014157

Nguyen Nam H K, Rafiee Roya, Parcha Phani K, Tagmount Abderrahmane, Rubnitz Jeffrey, Ribeiro Raul, Cao Xueyuan, Pounds Stanley B, Vulpe Christopher D, Lamba Jatinder K

Understanding the action mechanisms and safety of nanoparticles with functional toxicogenomics

利用功能性毒理基因组学了解纳米颗粒的作用机制和安全性

期刊:Nanomedicine

影响因子:3.9

doi:10.1080/17435889.2025.2523733

Yeerkenbieke, Buerlan; Li, Yanchen; Kiessling, Fabian; Lammers, Twan; Vulpe, Christopher; Pallares, Roger M

发表日期：2025

文献求助收藏

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening

与二维筛选相比，生理相关的三维 CRISPR 筛选能够增强对化学毒性机制的理解。

期刊:

影响因子:

doi:10.64898/2025.12.16.694776

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Christopher D

毒理研究

发表日期：2025

文献求助收藏

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

鉴定常见功能丧失基因及其在评估群体变异性和化学敏感性方面的潜在用途

期刊:

影响因子:

doi:10.64898/2025.12.16.694775

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Stuchal, Leah D; Martyniuk, Christopher J; Vulpe, Christopher D

发表日期：2025

文献求助收藏

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes.

帕金森病 LRRK2 突变会扰乱铁稳态，并促进人类神经元和星形胶质细胞中的氧化应激和铁死亡。

期刊:

影响因子:

doi:10.1101/2025.09.26.678370

Mamais Adamantios, Batchelor Richard D Jr, Chairmandurai Aravindraja, Subrahmanian Nitya, Maio Nunziata, Vulpe Christopher D, LaVoie Matthew J

CerS2 is a druggable target in triple-negative breast cancer.

CerS2 是三阴性乳腺癌的一个可药物靶点

期刊:

影响因子:

doi:10.1101/2025.08.15.670525

Alatawi Hissah, Nair Haritha H, Ai Lingbao, Mahmud Iqbal, Gour Abhishek, Singh Amandeep, Baek Doohyun, Yan Bowen, Maharjan Chandra K, Zhang Weizhou, Law Brian K, Zajac-Kaye Maria, Vulpe Christopher, Guryanova Olga A, Sharma Arun K, Garrett Timothy J, Sharma Abhisheak, Heldermon Coy D, Hong Sukwon, Narayan Satya

Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes

二氧化钛纳米颗粒在转化了人细胞色素P450 (CYP)基因的酵母报告细胞中表现出增强且独特的遗传毒性

期刊:Journal of Hazardous materials

影响因子:11.3

doi:10.1016/j.jhazmat.2024.134850

Jiang, Tao; Hou, Liyuan; Rahman, Sheikh Mokhlesur; Gong, Zixuan; Bai, Xueke; Vulpe, Christopher; Fasullo, Michael; Gu, April Z

Electron microscopy evidence of gadolinium toxicity being mediated through cytoplasmic membrane dysregulation

电子显微镜证据表明，钆的毒性是通过细胞质膜功能紊乱介导的。

期刊:Metallomics

影响因子:2.9

doi:10.1093/mtomcs/mfae042

Arino, Trevor; Faulkner, David; Bustillo, Karen C; An, Dahlia D; Jorgens, Danielle; Hébert, Solène; McKinley, Carla; Proctor, Michael; Loguinov, Alex; Vulpe, Christopher; Abergel, Rebecca J

YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

YAP处于人类癌症生物力学和耐药性交叉领域的前沿

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms241512491

Huang, Miao; Wang, Heyang; Mackey, Cole; Chung, Michael C; Guan, Juan; Zheng, Guangrong; Roy, Arkaprava; Xie, Mingyi; Vulpe, Christopher; Tang, Xin

cellMCD Effectively Discovers Drug Resistance and Sensitivity Genes for Acute Myeloid Leukemia

cellMCD 可有效发现急性髓系白血病的耐药基因和敏感性基因

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.

全基因组 CRISPR/Cas9 筛选鉴定出与儿童急性髓系白血病 (AML) 预后相关的 AraC-柔红霉素-依托泊苷反应调节剂

Understanding the action mechanisms and safety of nanoparticles with functional toxicogenomics

利用功能性毒理基因组学了解纳米颗粒的作用机制和安全性

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening

与二维筛选相比，生理相关的三维 CRISPR 筛选能够增强对化学毒性机制的理解。

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

鉴定常见功能丧失基因及其在评估群体变异性和化学敏感性方面的潜在用途

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes.

帕金森病 LRRK2 突变会扰乱铁稳态，并促进人类神经元和星形胶质细胞中的氧化应激和铁死亡。

CerS2 is a druggable target in triple-negative breast cancer.

CerS2 是三阴性乳腺癌的一个可药物靶点

Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes

二氧化钛纳米颗粒在转化了人细胞色素P450 (CYP)基因的酵母报告细胞中表现出增强且独特的遗传毒性

Electron microscopy evidence of gadolinium toxicity being mediated through cytoplasmic membrane dysregulation

电子显微镜证据表明，钆的毒性是通过细胞质膜功能紊乱介导的。

YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

YAP处于人类癌症生物力学和耐药性交叉领域的前沿