日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

cellMCD Effectively Discovers Drug Resistance and Sensitivity Genes for Acute Myeloid Leukemia

cellMCD 可有效发现急性髓系白血病的耐药基因和敏感性基因

Obodo, Dora; Nguyen, Nam H K; Cao, Xueyuan; Parcha, Phani Krishna; Vulpe, Christopher D; Lamba, Jatinder K; Pounds, Stanley B

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.

全基因组 CRISPR/Cas9 筛选鉴定出与儿童急性髓系白血病 (AML) 预后相关的 AraC-柔红霉素-依托泊苷反应调节剂

Nguyen Nam H K, Rafiee Roya, Parcha Phani K, Tagmount Abderrahmane, Rubnitz Jeffrey, Ribeiro Raul, Cao Xueyuan, Pounds Stanley B, Vulpe Christopher D, Lamba Jatinder K

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening

与二维筛选相比,生理相关的三维 CRISPR 筛选能够增强对化学毒性机制的理解。

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Christopher D

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

鉴定常见功能丧失基因及其在评估群体变异性和化学敏感性方面的潜在用途

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Stuchal, Leah D; Martyniuk, Christopher J; Vulpe, Christopher D

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes.

帕金森病 LRRK2 突变会扰乱铁稳态,并促进人类神经元和星形胶质细胞中的氧化应激和铁死亡。

Mamais Adamantios, Batchelor Richard D Jr, Chairmandurai Aravindraja, Subrahmanian Nitya, Maio Nunziata, Vulpe Christopher D, LaVoie Matthew J

The biology of mammalian multi-copper ferroxidases

哺乳动物多铜铁氧化酶的生物学

Helman, Sheridan L; Zhou, Jie; Fuqua, Brie K; Lu, Yan; Collins, James F; Chen, Huijun; Vulpe, Christopher D; Anderson, Gregory J; Frazer, David M

Multiple environmental stressors induce complex transcriptomic responses indicative of phenotypic outcomes in Western fence lizard

多种环境压力因素诱导西部栅栏蜥蜴产生复杂的转录组反应,这些反应预示着表型结果。

Gust, Kurt A; Chaitankar, Vijender; Ghosh, Preetam; Wilbanks, Mitchell S; Chen, Xianfeng; Barker, Natalie D; Pham, Don; Scanlan, Leona D; Rawat, Arun; Talent, Larry G; Quinn, Michael J Jr; Vulpe, Christopher D; Elasri, Mohamed O; Johnson, Mark S; Perkins, Edward J; McFarland, Craig A

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis

品系和年龄对HFE相关遗传性血色素沉着症小鼠模型肝脏基因表达谱的影响

Lee, Seung-Min; Loguinov, Alexandre; Fleming, Robert E; Vulpe, Christopher D

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium

实验室间对工程纳米材料体外细胞毒性和炎症反应的评估:NIEHS纳米氧化石墨烯联盟

Xia, Tian; Hamilton, Raymond F; Bonner, James C; Crandall, Edward D; Elder, Alison; Fazlollahi, Farnoosh; Girtsman, Teri A; Kim, Kwang; Mitra, Somenath; Ntim, Susana A; Orr, Galya; Tagmount, Mani; Taylor, Alexia J; Telesca, Donatello; Tolic, Ana; Vulpe, Christopher D; Walker, Andrea J; Wang, Xiang; Witzmann, Frank A; Wu, Nianqiang; Xie, Yumei; Zink, Jeffery I; Nel, Andre; Holian, Andrij

Mammalian iron transport

哺乳动物铁转运

Anderson, Gregory Jon; Vulpe, Christopher D