A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia.
中和 APOA5 单克隆抗体可减少毛细血管中脂蛋白脂肪酶的含量,并引发高甘油三酯血症。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2528664123
Yang Ye, Beigneux Anne P, Lowe Troy L, Chen Yan Q, Xie Katherine, Jung Hyesoo, Tu Yiping, Yu Rachel G, Scheithauer Julia L, Mehta Shailen, Wu Jerry, Alvarez Lindsay, Davidson W Sean, Birrane Gabriel, Remaley Alan T, Sviridov Denis, Ploug Michael, Zhen Eugene Y, Qian Yuewei, Sloan John H, Siegel Robert W, Konrad Robert J, Fong Loren G, Young Stephen G