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Cabozantinib for advanced grade 3 neuroendocrine tumors: subgroup analysis of the phase 3 CABINET trial (Alliance A021602)

卡博替尼治疗晚期 3 级神经内分泌肿瘤：3 期 CABINET 试验（Alliance A021602）的亚组分析

Strosberg, Jonathan R; Zemla, Tyler; Geyer, Susan; Pulsipher, Sydney; Ou, Fang-Shu; Behr, Spencer; Raj, Nitya; Vijayvergia, Namrata; Dasari, Arvind; O'Reilly, Eileen M; Meyerhardt, Jeffrey A; Wolin, Edward M; Halfdanarson, Thorvardur R; Chan, Jennifer A

肿瘤

肿瘤免疫

发表日期：2026

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Association between presurgical physical activity and urinary and sexual function in prostate cancer patients treated by radical prostatectomy: A prospective cohort study

前列腺癌根治性切除术患者术前体育活动与泌尿和性功能的关系：一项前瞻性队列研究

期刊:Urologic Oncology-Seminars and Original Investigations

影响因子:2.3

doi:10.1016/j.urolonc.2026.111063

Harper, Andrew; Khan, Momtafin; Imm, Kellie R; Grubb, Robert L 3rd; Kim, Eric H; Colditz, Graham A; Wolin, Kathleen Y; Kibel, Adam S; Sutcliffe, Siobhan; Yang, Lin

Impact of Age, Marital Status, Smoking, and Alcohol Consumption on Urinary and Sexual Function in Prostate Cancer Patients Treated With Radical Prostatectomy: A Prospective Cohort Study

年龄、婚姻状况、吸烟和饮酒对接受根治性前列腺切除术的前列腺癌患者泌尿和性功能的影响：一项前瞻性队列研究

期刊:Urology

影响因子:2

doi:10.1016/j.urology.2025.07.048

Zhang, Christie; Harper, Andrew; Imm, Kellie R; Grubb Iii, Robert L; Kim, Eric H; Colditz, Graham A; Wolin, Kathleen Y; Kibel, Adam S; Yang, Lin; Sutcliffe, Siobhan; Khan, Saira

Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors

卡博替尼治疗晚期神经内分泌肿瘤的3期临床试验

期刊:New England Journal of Medicine

影响因子:78.5

doi:10.1056/NEJMoa2403991

Chan, Jennifer A; Geyer, Susan; Zemla, Tyler; Knopp, Michael V; Behr, Spencer; Pulsipher, Sydney; Ou, Fang-Shu; Dueck, Amylou C; Acoba, Jared; Shergill, Ardaman; Wolin, Edward M; Halfdanarson, Thorvardur R; Konda, Bhavana; Trikalinos, Nikolaos A; Tawfik, Bernard; Raj, Nitya; Shaheen, Shagufta; Vijayvergia, Namrata; Dasari, Arvind; Strosberg, Jonathan R; Kohn, Elise C; Kulke, Matthew H; O'Reilly, Eileen M; Meyerhardt, Jeffrey A

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR能够对RNA-蛋白质相互作用进行多重映射，并揭示细胞应激下选择性翻译抑制的机制。

期刊:Cell

影响因子:45.5

doi:10.1016/j.cell.2025.06.042

Erica Wolin ，Jimmy K Guo ，Mario R Blanco ，Isabel N Goronzy ，Darvesh Gorhe ，Wenzhao Dong ，Andrew A Perez ，Abdurrahman Keskin ，Elizabeth Valenzuela ，Ahmed A Abdou ，Carl R Urbinati ，Ross Kaufhold ，H Tomas Rube ，Jailson Brito Querido ，Mitchell Guttman ，Marko Jovanovic

细胞生物学

发表日期：2025

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Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration

类器官培养促进小鼠成肌细胞去分化为能够完全再生肌肉的干细胞。

期刊:Nature Biotechnology

影响因子:41.7

doi:10.1038/s41587-024-02344-7

Price, Feodor D; Matyas, Mark N; Gehrke, Andrew R; Chen, William; Wolin, Erica A; Holton, Kristina M; Gibbs, Rebecca M; Lee, Alice; Singu, Pooja S; Sakakeeny, Jeffrey S; Poteracki, James M; Goune, Kelsey; Pfeiffer, Isabella T; Boswell, Sarah A; Sorger, Peter K; Srivastava, Mansi; Pfaff, Kathleen Lindahl; Gussoni, Emanuela; Buchanan, Sean M; Rubin, Lee L

EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis

EYA3通过调控NF-κB和CCL2抑制转移前微环境中的细胞毒性NK细胞，从而促进TNBC转移。

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.adt0504

Sheera R Rosenbaum ，Connor J Hughes ，Kaiah M Fields ，Stephen Connor Purdy ，Annika L Gustafson ，Arthur Wolin ，Drake Hampton ，Natasha M Shrivastava ，Nicholas Turner ，Etienne Danis ，Christopher Ebmeier ，Nicole Spoelstra ，Jennifer Richer ，Paul Jedlicka ，James C Costello ，Rui Zhao ，Heide L Ford

DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs

DIS3L2介导的RNA监视和细胞外囊泡包装可防止异常细胞RNA激活先天免疫。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2526318122

Williams, Sandra G; Sim, Soyeong; Guiblet, Wilfried M; George, Jubin; Jones, Jennifer C; Wolin, Sandra L

Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma

PAX3-FOXO1染色质占据对ETS1在重要致病基因上的依赖性揭示了融合阳性横纹肌肉瘤中新的可靶向脆弱性

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-024-03201-2

Hsieh, Joseph; Danis, Etienne P; Owens, Charles R; Parrish, Janet K; Nowling, Nathan L; Wolin, Arthur R; Purdy, Stephen Connor; Rosenbaum, Sheera R; Ivancevic, Atma M; Chuong, Edward B; Ford, Heide L; Jedlicka, Paul

Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens

Ro60和La自身抗原对RNA分子伴侣作用的机制性见解

Cabozantinib for advanced grade 3 neuroendocrine tumors: subgroup analysis of the phase 3 CABINET trial (Alliance A021602)

卡博替尼治疗晚期 3 级神经内分泌肿瘤：3 期 CABINET 试验（Alliance A021602）的亚组分析

Association between presurgical physical activity and urinary and sexual function in prostate cancer patients treated by radical prostatectomy: A prospective cohort study

前列腺癌根治性切除术患者术前体育活动与泌尿和性功能的关系：一项前瞻性队列研究

Impact of Age, Marital Status, Smoking, and Alcohol Consumption on Urinary and Sexual Function in Prostate Cancer Patients Treated With Radical Prostatectomy: A Prospective Cohort Study

年龄、婚姻状况、吸烟和饮酒对接受根治性前列腺切除术的前列腺癌患者泌尿和性功能的影响：一项前瞻性队列研究

Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors

卡博替尼治疗晚期神经内分泌肿瘤的3期临床试验

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR能够对RNA-蛋白质相互作用进行多重映射，并揭示细胞应激下选择性翻译抑制的机制。

Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration

类器官培养促进小鼠成肌细胞去分化为能够完全再生肌肉的干细胞。

EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis

EYA3通过调控NF-κB和CCL2抑制转移前微环境中的细胞毒性NK细胞，从而促进TNBC转移。

DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs

DIS3L2介导的RNA监视和细胞外囊泡包装可防止异常细胞RNA激活先天免疫。

Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma

PAX3-FOXO1染色质占据对ETS1在重要致病基因上的依赖性揭示了融合阳性横纹肌肉瘤中新的可靶向脆弱性